| Tag | Content |
|---|
| CPLM ID | CPLM-018013 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein bicaudal D homolog 2 |
Protein Synonyms/Alias | Bic-D 2 |
Gene Name | BICD2 |
Gene Synonyms/Alias | KIAA0699 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 349 | ISEIQKLKQQLMQME | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity). |
Sequence Annotation | REGION 663 803 Interacts with RAB6A (By similarity).
MOD_RES 2 2 N-acetylserine.
MOD_RES 190 190 Phosphoserine.
MOD_RES 224 224 Phosphoserine.
MOD_RES 343 343 Phosphoserine.
MOD_RES 395 395 Phosphoserine.
MOD_RES 582 582 Phosphoserine.
MOD_RES 821 821 Phosphothreonine.
MOD_RES 823 823 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 824 AA |
Protein Sequence | MSAPSEEEEY ARLVMEAQPE WLRAEVKRLS HELAETTREK IQAAEYGLAV LEEKHQLKLQ 60
FEELEVDYEA IRSEMEQLKE AFGQAHTNHK KVAADGESRE ESLIQESASK EQYYVRKVLE 120
LQTELKQLRN VLTNTQSENE RLASVAQELK EINQNVEIQR GRLRDDIKEY KFREARLLQD 180
YSELEEENIS LQKQVSVLRQ NQVEFEGLKH EIKRLEEETE YLNSQLEDAI RLKEISERQL 240
EEALETLKTE REQKNSLRKE LSHYMSINDS FYTSHLHVSL DGLKFSDDAA EPNNDAEALV 300
NGFEHGGLAK LPLDNKTSTP KKEGLAPPSP SLVSDLLSEL NISEIQKLKQ QLMQMEREKA 360
GLLATLQDTQ KQLEHTRGSL SEQQEKVTRL TENLSALRRL QASKERQTAL DNEKDRDSHE 420
DGDYYEVDIN GPEILACKYH VAVAEAGELR EQLKALRSTH EAREAQHAEE KGRYEAEGQA 480
LTEKVSLLEK ASRQDRELLA RLEKELKKVS DVAGETQGSL SVAQDELVTF SEELANLYHH 540
VCMCNNETPN RVMLDYYREG QGGAGRTSPG GRTSPEARGR RSPILLPKGL LAPEAGRADG 600
GTGDSSPSPG SSLPSPLSDP RREPMNIYNL IAIIRDQIKH LQAAVDRTTE LSRQRIASQE 660
LGPAVDKDKE ALMEEILKLK SLLSTKREQI TTLRTVLKAN KQTAEVALAN LKSKYENEKA 720
MVTETMMKLR NELKALKEDA ATFSSLRAMF ATRCDEYITQ LDEMQRQLAA AEDEKKTLNS 780
LLRMAIQQKL ALTQRLELLE LDHEQTRRGR AKAAPKTKPA TPSL 824 |
Gene Ontology | GO:0031410; C:cytoplasmic vesicle; ISS:BHF-UCL. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IDA:HPA. GO:0005886; C:plasma membrane; IDA:HPA. GO:0017137; F:Rab GTPase binding; ISS:BHF-UCL. GO:0072393; P:microtubule anchoring at microtubule organizing center; ISS:BHF-UCL. GO:0072385; P:minus-end-directed organelle transport along microtubule; ISS:BHF-UCL. |
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