CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010897
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 40S ribosomal protein S15 
Protein Synonyms/Alias
 RIG protein; RP52; S21; YS21 
Gene Name
 RPS15 
Gene Synonyms/Alias
 RPS21; YOL040C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
13NAKKRVFKTHSYRGVacetylation[1]
13NAKKRVFKTHSYRGVubiquitination[2]
24YRGVDLEKLLEMSTEacetylation[1]
24YRGVDLEKLLEMSTEubiquitination[2, 3]
35MSTEDFVKLAPARVRubiquitination[2, 3]
52FARGMTSKPAGFMKKubiquitination[2]
58SKPAGFMKKLRAAKLubiquitination[2, 3]
64MKKLRAAKLAAPENEacetylation[1]
64MKKLRAAKLAAPENEubiquitination[2, 3]
72LAAPENEKPAPVRTHacetylation[1]
72LAAPENEKPAPVRTHubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047
Functional Description
 Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 142 AA 
Protein Sequence
MSQAVNAKKR VFKTHSYRGV DLEKLLEMST EDFVKLAPAR VRRRFARGMT SKPAGFMKKL 60
RAAKLAAPEN EKPAPVRTHM RNMIIVPEMI GSVVGIYNGK AFNQVEIRPE MLGHYLGEFS 120
ITYTPVRHGR AGATTSRFIP LK 142 
Gene Ontology
 GO:0022627; C:cytosolic small ribosomal subunit; NAS:SGD.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; NAS:SGD.
 GO:0002181; P:cytoplasmic translation; NAS:SGD.
 GO:0006407; P:rRNA export from nucleus; IMP:SGD. 
Interpro
 IPR002222; Ribosomal_S19.
 IPR020934; Ribosomal_S19_CS.
 IPR023575; Ribosomal_S19_SF.
 IPR005713; Ribosomal_S19A/S15e. 
Pfam
 PF00203; Ribosomal_S19 
SMART
  
PROSITE
 PS00323; RIBOSOMAL_S19 
PRINTS
 PR00975; RIBOSOMALS19.