UniProt Accession

 GLYAT_RAT; Q5PQT3; Q7TP56 

Genbank Protein ID

 AY325192; BC087043 

Genbank Nucleotide ID

 AAP92593.1; AAH87043.1 

Protein Name

 Glycine N-acyltransferase 

Protein Synonyms/Alias

 Acyl-CoA:glycine N-acyltransferase; AAc; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase; Liver regeneration-related protein LRRG067 

Gene Name

 Glyat 

Gene Synonyms/Alias

 Ab2-132 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
16	QMLQMLEKSLKKYLP	acetylation	[1]
19	QMLEKSLKKYLPESL	acetylation	[1]
20	MLEKSLKKYLPESLK	acetylation	[1]
113	SSQSHLNKAIQNLAS	acetylation	[1]
159	NLSPGSGKPKAINQE	acetylation	[1]
183	THAALVNKFWLFGGN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid (By similarity). 

Sequence Annotation

 MOD_RES 20 20 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Acyltransferase; Complete proteome; Detoxification; Mitochondrion; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0047961; F:glycine N-acyltransferase activity; IEA:EC.
 GO:0047962; F:glycine N-benzoyltransferase activity; ISS:UniProtKB.
 GO:0006544; P:glycine metabolic process; ISS:UniProtKB.
 GO:0032787; P:monocarboxylic acid metabolic process; ISS:UniProtKB.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR010313; Glycine_N-acyltransferase.
 IPR013652; Glycine_N-acyltransferase_C.
 IPR015938; Glycine_N-acyltransferase_N. 

Pfam

 PF08444; Gly_acyl_tr_C
 PF06021; Gly_acyl_tr_N 

SMART

  

PROSITE

  

PRINTS