| Tag | Content |
|---|
| CPLM ID | CPLM-003331 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-deoxy-D-manno-octulosonic acid transferase |
Protein Synonyms/Alias | Kdo transferase; Bifunctional Kdo transferase; Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase; Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase |
Gene Name | waaA |
Gene Synonyms/Alias | kdtA; b3633; JW3608 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | GFYRHPLKPGGIMLH | acetylation | [1] | | 99 | RVQSAFGKDVQHVYL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A. |
Sequence Annotation | REGION 268 269 CMP-Kdo binding (By similarity).
REGION 309 311 CMP-Kdo binding (By similarity).
REGION 335 338 CMP-Kdo binding (By similarity).
ACT_SITE 60 60 Proton acceptor (By similarity). |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 425 AA |
Protein Sequence | MLELLYTALL YLIQPLIWIR LWVRGRKAPA YRKRWGERYG FYRHPLKPGG IMLHSVSVGE 60
TLAAIPLVRA LRHRYPDLPI TVTTMTPTGS ERVQSAFGKD VQHVYLPYDL PDALNRFLNK 120
VDPKLVLIME TELWPNLIAA LHKRKIPLVI ANARLSARSA AGYAKLGKFV RRLLRRITLI 180
AAQNEEDGAR FVALGAKNNQ VTVTGSLKFD ISVTPQLAAK AVTLRRQWAP HRPVWIATST 240
HEGEESVVIA AHQALLQQFP NLLLILVPRH PERFPDAINL VRQAGLSYIT RSSGEVPSTS 300
TQVVVGDTMG ELMLLYGIAD LAFVGGSLVE RGGHNPLEAA AHAIPVLMGP HTFNFKDICA 360
RLEQASGLIT VTDATTLAKE VSSLLTDADY RSFYGRHAVE VLYQNQGALQ RLLQLLEPYL 420
PPKTH 425 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:EcoliWiki. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016740; F:transferase activity; IDA:EcoliWiki. GO:0036104; P:Kdo2-lipid A biosynthetic process; IEA:UniProtKB-UniPathway. GO:0009245; P:lipid A biosynthetic process; IMP:EcoliWiki. GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |