UniProt Accession

 H2B_DROME; P02283; Q4ABE1; Q9W5U7 

Genbank Protein ID

 X14215; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134; AE014134 

Genbank Nucleotide ID

 CAA32432.1; AAN11124.1; AAZ66483.1; AAZ66487.1; AAZ66492.1; AAZ66496.1; AAZ66501.1; AAZ66506.1; AAZ66511.1; AAZ66521.1; AAZ66531.1; AAZ66576.1; AAZ66571.1; AAZ66566.1; AAZ66561.1; AAZ66556.1; AAZ66551.1; AAZ66546.1; AAZ66541.1; AAZ66536.1; AAZ66479.1; AAZ66581.1; AAZ66526.1; AAZ66516.1 

Protein Name

 Histone H2B 

Protein Synonyms/Alias

  

Gene Name

 His2B; His2B:CG17949; His2B:CG33868; His2B:CG33870; His2B:CG33872; His2B:CG33874; His2B:CG33876; His2B:CG33878; His2B:CG33880; His2B:CG33882; His2B:CG33884; His2B:CG33886; His2B:CG33888; His2B:CG33890; His2B:CG33892; His2B:CG33894; His2B:CG33896; His2B:CG33898; His2B:CG33900; His2B:CG33902; His2B:CG33904; His2B:CG33906; His2B:CG33908; His2B:CG33910 

Gene Synonyms/Alias

 CG17949; CG33868; CG33870; CG33872; CG33874; CG33876; CG33878; CG33880; CG33882; CG33884; CG33886; CG33888; CG33890; CG33892; CG33894; CG33896; CG33898; CG33900; CG33902; CG33904; CG33906; CG33908; CG33910 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
8	MPPKTSGKAAKKAGK	acetylation	[1]
11	KTSGKAAKKAGKAQK	acetylation	[1]
12	TSGKAAKKAGKAQKN	acetylation	[1]
15	KAAKKAGKAQKNITK	acetylation	[1]
18	KKAGKAQKNITKTDK	acetylation	[1]
22	KAQKNITKTDKKKKR	acetylation	[1]
44	IYIYKVLKQVHPDTG	acetylation	[1]
44	IYIYKVLKQVHPDTG	succinylation	[2]
106	LLPGELAKHAVSEGT	acetylation	[1]
114	HAVSEGTKAVTKYTS	succinylation	[2]
118	EGTKAVTKYTSSK**	acetylation	[1]
118	EGTKAVTKYTSSK**	succinylation	[2]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]
 [2] Lysine succinylation and lysine malonylation in histones.
 Xie Z, Dai J, Dai L, Tan M, Cheng Z, Wu Y, Boeke JD, Zhao Y.
 Mol Cell Proteomics. 2012 May;11(5):100-7. [PMID: 22389435] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-methylproline; partial.
 MOD_RES 34 34 Phosphoserine; by TAF1.
 CARBOHYD 110 110 O-linked (GlcNAc...) (By similarity).
 CROSSLNK 118 118 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Glycoprotein; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 123 AA 

Protein Sequence

Gene Ontology

 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0000786; C:nucleosome; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0006334; P:nucleosome assembly; NAS:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.