CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010582
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fascin 
Protein Synonyms/Alias
  
Gene Name
 Fscn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
353TLRASNGKFVTAKKNacetylation[1]
399HGFIGCRKVTGTLDAubiquitination[2]
471KVGGRYLKGDHAGVLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility. 
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 39 39 Phosphoserine; by PKC (By similarity).  
Keyword
 Acetylation; Actin-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MTANGTAEAV QIQFGLISCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV 60
CLRSHLGPYL AADKDGNVTC EREVPDGDCR FLVVAHDDGR WSLQSEAHRR YFGGTEDRLS 120
CFAQSVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA 180
FQDQRYSVQT SDHRFLRHDG RLVARPEPAT GFTLEFRSGK VAFRDCEGRY LAPSGPSGTL 240
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR 300
DTRKCAFRTH TGKYWTLTAT GGVQSTASTK NASCYFDIEW CERRITLRAS NGKFVTAKKN 360
GQLAATVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND 420
GAYNIKDSTG KYWTVGSDSS VTSSSDTPVD FFLEFCDYNK VALKVGGRYL KGDHAGVLKA 480
CAETIDPATL WEY 493 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0030175; C:filopodium; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0071437; C:invadopodium; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; IDA:RGD.
 GO:0005902; C:microvillus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0001726; C:ruffle; IDA:RGD.
 GO:0001725; C:stress fiber; IDA:RGD.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0051017; P:actin filament bundle assembly; IDA:UniProtKB.
 GO:0048870; P:cell motility; ISS:UniProtKB.
 GO:0071460; P:cellular response to cell-matrix adhesion; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain.
 IPR024703; Fascin_metazoans. 
Pfam
 PF06268; Fascin 
SMART
  
PROSITE
  
PRINTS