UniProt Accession

 K7ERV3_HUMAN; K7ERV3 

Genbank Protein ID

 AC021593; AC087645 

Genbank Nucleotide ID

  

Protein Name

 Thymidine kinase 

Protein Synonyms/Alias

  

Gene Name

 TK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
236	QPAGPDNKENCPVPG	ubiquitination	[1]
253	GEAVAARKLFAPQQI	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; DNA synthesis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004797; F:thymidine kinase activity; IEA:EC.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR001267; Thymidine_kinase.
 IPR020633; Thymidine_kinase_CS. 

Pfam

 PF00265; TK 

SMART

  

PROSITE

 PS00603; TK_CELLULAR_TYPE 

PRINTS