UniProt Accession

 E9PZF0_MOUSE; E9PZF0 

Genbank Protein ID

 AL662838 

Genbank Nucleotide ID

  

Protein Name

 Nucleoside diphosphate kinase 

Protein Synonyms/Alias

  

Gene Name

 Gm20390 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	ERTFIAIKPDGVQRG	acetylation	[1, 2, 3]
12	ERTFIAIKPDGVQRG	succinylation	[3]
12	ERTFIAIKPDGVQRG	ubiquitination	[4]
26	GLVGEIIKRFEQKGF	acetylation	[1, 3]
26	GLVGEIIKRFEQKGF	succinylation	[3]
26	GLVGEIIKRFEQKGF	ubiquitination	[4]
31	IIKRFEQKGFRLVGL	acetylation	[1]
39	GFRLVGLKFLQASED	acetylation	[1]
39	GFRLVGLKFLQASED	ubiquitination	[4]
49	QASEDLLKEHYTDLK	acetylation	[1, 2]
49	QASEDLLKEHYTDLK	ubiquitination	[4]
56	KEHYTDLKDRPFFTG	acetylation	[1]
56	KEHYTDLKDRPFFTG	ubiquitination	[4]
85	WEGLNVVKTGRVMLG	acetylation	[1]
100	ETNPADSKPGTIRGD	acetylation	[1, 2, 3, 5]
100	ETNPADSKPGTIRGD	succinylation	[3]
100	ETNPADSKPGTIRGD	ubiquitination	[4]
154	GFRLVAMKFLRASEE	acetylation	[1]
154	GFRLVAMKFLRASEE	ubiquitination	[4]
164	RASEEHLKQHYIDLK	acetylation	[1, 2, 5]
164	RASEEHLKQHYIDLK	ubiquitination	[4]
171	KQHYIDLKDRPFFPG	acetylation	[2, 6]
171	KQHYIDLKDRPFFPG	ubiquitination	[4]
200	WEGLNVVKTGRVMLG	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.