CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Slc25a1 
Protein Synonyms/Alias
  
Gene Name
 Slc25a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35TCGMPKVKFIHDQTSacetylation[1]
46DQTSSNPKYRGFFHGacetylation[1, 2]
46DQTSSNPKYRGFFHGubiquitination[3]
64IIREQGLKGTYQGLTubiquitination[3]
76GLTATVLKQGSNQAIacetylation[2]
141MQGLEAHKYRNTLDCacetylation[2]
151NTLDCGLKILKNEGPacetylation[2]
151NTLDCGLKILKNEGPubiquitination[3]
154DCGLKILKNEGPKAFacetylation[2, 4, 5]
154DCGLKILKNEGPKAFsuccinylation[5]
163EGPKAFYKGTVPRLGacetylation[2, 5]
163EGPKAFYKGTVPRLGsuccinylation[5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 197 AA 
Protein Sequence
XAASAPCSTA PSPRRLSGLG CSSSSATTCG MPKVKFIHDQ TSSNPKYRGF FHGVREIIRE 60
QGLKGTYQGL TATVLKQGSN QAIRFFVMTS LRNWYQGDNH NKPMNPLITG VFGATAGAAS 120
VFGNTPLDVI KTRMQGLEAH KYRNTLDCGL KILKNEGPKA FYKGTVPRLG RVCLDVAIVF 180
IIYDEVVKLL NKVWKTD 197 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS