UniProt Accession

 SNX3_MOUSE; O70492 

Genbank Protein ID

 AF062482 

Genbank Nucleotide ID

 AAC16017.1 

Protein Name

 Sorting nexin-3 

Protein Synonyms/Alias

 SDP3 protein 

Gene Name

 Snx3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
54	TTYEIRVKTNLPIFK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation (By similarity). 

Sequence Annotation

 DOMAIN 27 151 PX.
 BINDING 70 70 Phosphatidylinositol 3-phosphate (By
 BINDING 72 72 Phosphatidylinositol 3-phosphate; via
 BINDING 95 95 Phosphatidylinositol 3-phosphate (By
 BINDING 118 118 Phosphatidylinositol 3-phosphate (By
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Endosome; Lipid-binding; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR001683; Phox. 

Pfam

 PF00787; PX 

SMART

 SM00312; PX 

PROSITE

 PS50195; PX 

PRINTS