CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methyl-CpG-binding domain protein 1 
Protein Synonyms/Alias
  
Gene Name
 PCM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39MDWGAQQKKANRSSEubiquitination[1]
51SSEKNKKKFGVESDKubiquitination[2, 3]
58KFGVESDKRVTNDISubiquitination[3, 4]
78GVGRRRTKTPHTFPHubiquitination[3, 4]
102PEQAELEKLKQRINFubiquitination[1, 2, 3, 5]
104QAELEKLKQRINFSDubiquitination[2, 3]
139RQLSENRKPFNFLPMubiquitination[2, 3]
152PMQINTNKSKDASTNubiquitination[2, 3]
172TIGSAQCKELFASALubiquitination[1]
218QIRDYITKASSMREDubiquitination[1, 2, 3, 4]
229MREDLVEKNERSANVubiquitination[1, 3, 4]
247THLIDHLKEQEKSYMubiquitination[3]
255EQEKSYMKFLKKILAubiquitination[2, 3]
258KSYMKFLKKILARDPubiquitination[3]
259SYMKFLKKILARDPQubiquitination[3]
277MEEIENLKKQHDLLKubiquitination[1, 3, 4, 5, 6, 7]
278EEIENLKKQHDLLKRubiquitination[3]
382REVSQSRKPSASERLubiquitination[3, 7]
393SERLPDEKVELFSKMubiquitination[1, 2, 3, 4, 5, 6, 7, 8, 9]
399EKVELFSKMRVLQEKubiquitination[1, 2, 3, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [9] Proteomic snapshot of the EGF-induced ubiquitin network.
 Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, Polo S.
 Mol Syst Biol. 2011 Jan 18;7:462. [PMID: 21245847] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV 60
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD 120
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS 180
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT 240
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ 300
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA 360
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQ 408 
Gene Ontology
 GO:0034451; C:centriolar satellite; IEA:Compara.
 GO:0000242; C:pericentriolar material; IEA:Compara.
 GO:0022027; P:interkinetic nuclear migration; IEA:Compara.
 GO:0034454; P:microtubule anchoring at centrosome; IEA:Compara.
 GO:0050768; P:negative regulation of neurogenesis; IEA:Compara.
 GO:0097150; P:neuronal stem cell maintenance; IEA:Compara.
 GO:0071539; P:protein localization to centrosome; IEA:Compara. 
Interpro
 IPR024138; Pericentriolar_Pcm1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS