UniProt Accession

 PORED_MOUSE; Q9WUP4; D3YZB6; D3Z3J5; Q3UU82; Q8BGE3 

Genbank Protein ID

 AF146793; AK040198; AK075635; AK138681; AK139290; AK162527; AC147239; BC145647 

Genbank Nucleotide ID

 AAD30567.1; BAC30537.1; BAC35871.1; BAE23745.1; BAE23944.1; BAE36955.1; AAI45648.1 

Protein Name

 Polyprenol reductase 

Protein Synonyms/Alias

 3-oxo-5-alpha-steroid 4-dehydrogenase 3; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3 

Gene Name

 Srd5a3 

Gene Synonyms/Alias

 Srd5a2l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
128	QALEMESKASRMPAA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; ISS:UniProtKB.
 GO:0047751; F:cholestenone 5-alpha-reductase activity; IEA:EC.
 GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
 GO:0019348; P:dolichol metabolic process; IMP:UniProtKB.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IMP:UniProtKB.
 GO:0016095; P:polyprenol catabolic process; IMP:UniProtKB.
 GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 

Pfam

 PF02544; Steroid_dh 

SMART

  

PROSITE

 PS50244; S5A_REDUCTASE 

PRINTS