CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020954
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 
Protein Synonyms/Alias
 Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58; Protein CGI-58 
Gene Name
 Abhd5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
316SIQSLRPKSYVKTIAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. 
Sequence Annotation
 MOTIF 329 334 HXXXXD motif.  
Keyword
 Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Fatty acid metabolism; Lipid biosynthesis; Lipid droplet; Lipid metabolism; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MKAMAAEEEV DSADAGGGSG WLTGWLPTWC PTSTSHLKEA EEKMLKCVPC TYKKEPVRIS 60
NGNRIWTLMF SHNISSKTPL VLLHGFGGGL GLWALNFEDL STDRPVYAFD LLGFGRSSRP 120
RFDSDAEEVE NQFVESIEEW RCALRLDKMI LLGHNLGGFL AAAYSLKYPS RVSHLILVEP 180
WGFPERPDLA DQERPIPVWI RALGAALTPF NPLAGLRIAG PFGLSLVQRL RPDFKRKYSS 240
MFEDDTVTEY IYHCNVQTPS GETAFKNMTI PYGWAKRPML QRIGGLHPDI PVSVIFGARS 300
CIDGNSGTSI QSLRPKSYVK TIAILGAGHY VYADQPEEFN QKVKEICHTV D 351 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC.
 GO:0042171; F:lysophosphatidic acid acyltransferase activity; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0010891; P:negative regulation of sequestering of triglyceride; IDA:UniProtKB.
 GO:0006654; P:phosphatidic acid biosynthetic process; ISS:UniProtKB.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IDA:MGI.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IDA:UniProtKB. 
Interpro
 IPR000073; AB_hydrolase_1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00111; ABHYDROLASE.