UniProt Accession

 IGHA1_HUMAN; P01876 

Genbank Protein ID

 J00220 

Genbank Nucleotide ID

 AAC82528.1 

Protein Name

 Ig alpha-1 chain C region 

Protein Synonyms/Alias

  

Gene Name

 IGHA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
168	TWTPSSGKSAVQGPP	ubiquitination	[1]
212	TAAYPESKTPLTATL	ubiquitination	[1]
258	LARGFSPKDVLVRWL	glycation	[2]
258	LARGFSPKDVLVRWL	ubiquitination	[1]
275	SQELPREKYLTWASR	ubiquitination	[1]
306	RVAAEDWKKGDTFSC	ubiquitination	[1]
307	VAAEDWKKGDTFSCM	ubiquitination	[1]
327	LPLAFTQKTIDRLAG	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. 

Sequence Annotation

 DOMAIN 6 98 Ig-like 1.
 DOMAIN 125 220 Ig-like 2.
 DOMAIN 228 330 Ig-like 3.
 BINDING 352 352 Multimeric 3-hydroxykynurenine
 CARBOHYD 105 105 O-linked (GalNAc...).
 CARBOHYD 111 111 O-linked (GalNAc...).
 CARBOHYD 113 113 O-linked (GalNAc...).
 CARBOHYD 119 119 O-linked (GalNAc...).
 CARBOHYD 121 121 O-linked (GalNAc...).
 CARBOHYD 144 144 N-linked (GlcNAc...) (complex).
 CARBOHYD 340 340 N-linked (GlcNAc...).
 DISULFID 14 14 Interchain (with light chain).
 DISULFID 26 85
 DISULFID 77 101
 DISULFID 122 122 Interchain (with heavy chain).
 DISULFID 123 180 Or C-123 with C-182.
 DISULFID 147 204
 DISULFID 182 182 Interchain (with heavy chain) (or with C-
 DISULFID 192 192 Interchain (with heavy chain of another
 DISULFID 250 313
 DISULFID 352 352 Interchain (with J chain); in oligomeric  

Keyword

 3D-structure; Chromophore; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0003823; F:antigen binding; NAS:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB.
 GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS