UniProt Accession

 DYL2_MOUSE; Q9D0M5; A7M7R8; Q3TFB4 

Genbank Protein ID

 AY029255; AK011284; AK028319; AK049645; AK078434; AK160114; AK169212; AL606805; BC011289; BC040822 

Genbank Nucleotide ID

 AAK38749.1; BAB27516.1; BAC25877.1; BAC33856.1; BAC37271.1; BAE35638.1; BAE40984.1; CAO91831.1; AAH11289.1; AAH40822.1 

Protein Name

 Dynein light chain 2, cytoplasmic 

Protein Synonyms/Alias

 8 kDa dynein light chain b; DLC8; DLC8b; Dynein light chain LC8-type 2 

Gene Name

 Dynll2 

Gene Synonyms/Alias

 Dlc2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	MEKYNIEKDIAAYIK	acetylation	[1]
44	DIAAYIKKEFDKKYN	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030286; C:dynein complex; NAS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0016459; C:myosin complex; IDA:UniProtKB.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0046907; P:intracellular transport; NAS:UniProtKB.
 GO:0007017; P:microtubule-based process; IEA:InterPro.
 GO:0008039; P:synaptic target recognition; IEA:Compara. 

Interpro

 IPR019763; Dynein_light_1/2_CS.
 IPR001372; Dynein_light_chain_typ-1/2. 

Pfam

 PF01221; Dynein_light 

SMART

  

PROSITE

 PS01239; DYNEIN_LIGHT_1 

PRINTS