CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034541
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG142036 
Protein Synonyms/Alias
 Protein Acad12 
Gene Name
 Acad12 
Gene Synonyms/Alias
 mCG_142036 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
267RYGTEEQKARWLVPLacetylation[1]
334KLCVFMGKTDPQAPRacetylation[1]
439MSRTAFGKPLVEQGTacetylation[1, 2, 3, 4, 5]
439MSRTAFGKPLVEQGTsuccinylation[4]
478LMDVAGNKAAALEMAacetylation[1, 4, 5]
478LMDVAGNKAAALEMAsuccinylation[4]
535RLGDDQLKVAKMELKacetylation[1, 2, 4, 5, 6]
535RLGDDQLKVAKMELKsuccinylation[4]
538DDQLKVAKMELKNQSacetylation[1, 2, 4, 5]
538DDQLKVAKMELKNQSsuccinylation[4]
538DDQLKVAKMELKNQSsuccinylation[4]
542KVAKMELKNQSRLQEacetylation[1, 3, 4, 5]
542KVAKMELKNQSRLQEsuccinylation[4]
542KVAKMELKNQSRLQEsuccinylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 555 AA 
Protein Sequence
MWVRRLFQPS TLHWAWRTTA LNHPLGRHQG GLRWTHSGGR SYRAVIFDTG GVLVPSPGTV 60
AVGQASSATA QQSGKLTESM AELAWDFATK EGFRVFKEMP ATKTLSRSYH AWAGPRSPRT 120
PKGVRGHSTV AAASPSHEAK GGLVISPEGL SPAVRKLYEQ LVQFIEQKVY PLEPELQRHQ 180
ASANRWSPSP LIEDLKEKAK AEGLWNLFLP LETDPEKKYG AGLTNVEYAH LCEVMGMSLY 240
ASEIFNCSVP DMGTMEILVR YGTEEQKARW LVPLLEGRIH SCFAMTDRKV ASSDASNIEA 300
SIKEEDNSYV INGHKWWTSG ILHPHCKLCV FMGKTDPQAP RHQQQSMLLV PMDSPGITVI 360
RPLSVFGLED PPGGFAEVQF KDVRVPKENI ILGPGRAFEI AQGRLGRARI HNSMRLIGYS 420
ERALALMKTR VMSRTAFGKP LVEQGTILAD IARSRVEIEQ ARLLVLKAAH LMDVAGNKAA 480
ALEMAMIKMV VPSMANQVID RAIQAFGAAG LSSDYPLAQF FGWAQTLRLG DDQLKVAKME 540
LKNQSRLQEP AARRV 555 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. 
Interpro
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
  
PRINTS