CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008832
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional purine biosynthesis protein ADE16 
Protein Synonyms/Alias
 Phosphoribosylaminoimidazolecarboxamide formyltransferase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase 
Gene Name
 ADE16 
Gene Synonyms/Alias
 YLR028C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
15AILSVYDKTGLLDLAacetylation[1]
360LSKKKNGKYCILQIDubiquitination[2]
400IINQSTFKEIVSKNKacetylation[1]
436SNSVCYAKNGMVVGLubiquitination[2]
520EVPEPFTKEERLEWLubiquitination[2]
556RAVQSGVKFITAPSGubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Multifunctional enzyme; Purine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MGKYTKTAIL SVYDKTGLLD LAKGLVENNV RILASGGTAN MVREAGFPVD DVSSITHAPE 60
MLGGRVKTLH PAVHAGILAR NLEGDEKDLK EQHIDKVDFV VCNLYPFKET VAKIGVTVQE 120
AVEEIDIGGV TLLRAAAKNH SRVTILSDPN DYSIFLQDLS KDGEISQDLR NRFALKAFEH 180
TADYDAAISD FFRKQYSEGK AQLPLRYGCN PHQRPAQAYI TQQEELPFKV LCGTPGYINL 240
LDALNSWPLV KELSASLNLP AAASFKHVSP AGAAVGLPLS DVERQVYFVN DMEDLSPLAC 300
AYARARGADR MSSFGDFIAL SNIVDVATAK IISKEVSDGV IAPGYEPEAL NILSKKKNGK 360
YCILQIDPNY VPGQMESREV FGVTLQQKRN DAIINQSTFK EIVSKNKALT EQAVIDLTVA 420
TLVLKYTQSN SVCYAKNGMV VGLGAGQQSR IHCTRLAGDK TDNWWLRQHP KVLNMKWAKG 480
IKRADKSNAI DLFVTGQRIE GPEKVDYESK FEEVPEPFTK EERLEWLSKL NNVSLSSDAF 540
FPFPDNVYRA VQSGVKFITA PSGSVMDKVV FQAADSFDIV YVENPIRLFH H 591 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0003937; F:IMP cyclohydrolase activity; IDA:SGD.
 GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IDA:SGD.
 GO:0006189; P:'de novo' IMP biosynthetic process; IMP:SGD.
 GO:0009060; P:aerobic respiration; IEP:SGD.
 GO:0030437; P:ascospore formation; IEP:SGD. 
Interpro
 IPR024051; AICAR_Tfase_dom.
 IPR024050; AICAR_Tfase_insert_dom.
 IPR002695; AICARFT_IMPCHas.
 IPR016193; Cytidine_deaminase-like.
 IPR011607; MGS-like_dom. 
Pfam
 PF01808; AICARFT_IMPCHas
 PF02142; MGS 
SMART
 SM00798; AICARFT_IMPCHas
 SM00851; MGS 
PROSITE
  
PRINTS