| Tag | Content |
|---|
| CPLM ID | CPLM-013006 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synembryn-A |
Protein Synonyms/Alias | Protein Ric-8A |
Gene Name | Ric8a |
Gene Synonyms/Alias | Ric8 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 488 | KLVNMFDKLSRHRVI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)- coupled receptor-mediated ERK activation (By similarity). |
Sequence Annotation | MOD_RES 199 199 Phosphothreonine.
MOD_RES 435 435 Phosphoserine.
MOD_RES 440 440 Phosphothreonine (By similarity).
MOD_RES 501 501 Phosphoserine (By similarity).
MOD_RES 522 522 Phosphoserine (By similarity).
MOD_RES 523 523 Phosphoserine (By similarity).
MOD_RES 527 527 Phosphoserine (By similarity). |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 530 AA |
Protein Sequence | MEPRAVADAL ETGEEDAVTE ALRSFNREHS QSFTFDDAQQ EDRKRLAKLL VSVLEQGLSP 60
KHRVTWLQTI RILSRDRSCL DSFASRQSLH ALACYADITV SEEPIPQSPD MDVLLESLKC 120
LCNLVLSSPT AQMLAAEARL VVRLAERVGL YRKRSYPHEV QFFDLRLLFL LTALRTDVRQ 180
QLFQELHGVR LLTDALELTL GVAPKENPPV MLPAQETERA MEILKVLFNI TFDSVKREVD 240
EEDAALYRYL GTLLRHCVMV EAAGDRTEEF HGHTVNLLGN LPLKCLDVLL ALELHEGSLE 300
FMGVNMDVIS ALLAFLEKRL HQTHRLKECV APVLNVLTEC ARMHRPARKF LKAQVLPPLR 360
DVRTRPEVGD LLRNKLVRLM THLDTDVKRV AAEFLFVLCS ESVPRFIKYT GYGNAAGLLA 420
ARGLMAGGRP EGQYSEDEDT DTEEYREAKA SINPVTGRVE EKPPNPMEGM TEEQKEHEAM 480
KLVNMFDKLS RHRVIQPMGM SPRGHLTSLQ DAMCETMEGQ LSSDPDSDPD 530 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IDA:MGI. GO:0071711; P:basement membrane organization; IMP:MGI. GO:0042074; P:cell migration involved in gastrulation; IMP:MGI. GO:0070586; P:cell-cell adhesion involved in gastrulation; IMP:MGI. GO:0001701; P:in utero embryonic development; IMP:MGI. GO:0001944; P:vasculature development; IMP:MGI. GO:0008542; P:visual learning; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |