UniProt Accession

 VDAC2_RAT; P81155; Q9JI32 

Genbank Protein ID

 AB039663; AF268468; BC063164 

Genbank Nucleotide ID

 BAB13474.1; AAF80116.1; AAH63164.1 

Protein Name

 Voltage-dependent anion-selective channel protein 2 

Protein Synonyms/Alias

 VDAC-2; B36-VDAC; Outer mitochondrial membrane protein porin 2 

Gene Name

 Vdac2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
32	AARDIFNKGFGFGLV	acetylation	[1, 2]
40	GFGFGLVKLDVKTKS	acetylation	[2]
75	GTLETKYKWCEYGLT	acetylation	[1, 2]
121	TFSPNTGKKSGKIKS	acetylation	[2]
236	TRFGIAAKYQLDPTA	acetylation	[2]
248	PTASISAKVNNSSLI	acetylation	[2]
278	LSALVDGKSFNAGGH	acetylation	[2]

Reference

 [1] Proteomics of mitochondrial inner and outer membranes.
 Distler AM, Kerner J, Hoppel CL.
 Proteomics. 2008 Oct;8(19):4066-82. [PMID: 18763707]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity). 

Sequence Annotation

 NP_BIND 254 256 NAD (By similarity).
 NP_BIND 272 276 NAD (By similarity).
 MOD_RES 32 32 N6-acetyllysine (By similarity).
 MOD_RES 237 237 Phosphotyrosine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.