CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTPase IMAP family member 5 
Protein Synonyms/Alias
 Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3 
Gene Name
 GIMAP5 
Gene Synonyms/Alias
 IAN4L1; IAN5; IMAP3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MGGFQRGKYGTMAEGubiquitination[1, 2, 3]
35LRIILVGKTGCGKSAubiquitination[2]
40VGKTGCGKSATGNSIubiquitination[1, 2]
56GQPVFESKLRAQSVTubiquitination[1, 2, 3]
69VTRTCQVKTGTWNGRubiquitination[2]
77TGTWNGRKVLVVDTPubiquitination[2, 3]
135TVAIRKVKEVFGTGAubiquitination[2]
255KVEWQVEKHKQELREubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity). 
Sequence Annotation
 NP_BIND 34 42 GTP (By similarity).
 NP_BIND 152 154 GTP (By similarity).
 BINDING 55 55 GTP (By similarity).
 BINDING 189 189 GTP (By similarity).  
Keyword
 Alternative splicing; Complete proteome; GTP-binding; Lysosome; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 307 AA 
Protein Sequence
MGGFQRGKYG TMAEGRSEDN LSATPPALRI ILVGKTGCGK SATGNSILGQ PVFESKLRAQ 60
SVTRTCQVKT GTWNGRKVLV VDTPSIFESQ ADTQELYKNI GDCYLLSAPG PHVLLLVIQL 120
GRFTAQDTVA IRKVKEVFGT GAMRHVVILF THKEDLGGQA LDDYVANTDN CSLKDLVREC 180
ERRYCAFNNW GSVEEQRQQQ AELLAVIERL GREREGSFHS NDLFLDAQLL QRTGAGACQE 240
DYRQYQAKVE WQVEKHKQEL RENESNWAYK ALLRVKHLML LHYEIFVFLL LCSILFFIIF 300
LFIFHYI 307 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0043011; P:myeloid dendritic cell differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032689; P:negative regulation of interferon-gamma production; IEA:Compara.
 GO:0050995; P:negative regulation of lipid catabolic process; IEA:Compara.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0050868; P:negative regulation of T cell activation; IEA:Compara.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Compara.
 GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Compara.
 GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Compara.
 GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Compara.
 GO:0045838; P:positive regulation of membrane potential; IEA:Compara.
 GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0001659; P:temperature homeostasis; IEA:Compara. 
Interpro
 IPR006703; AIG1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF04548; AIG1 
SMART
  
PROSITE
  
PRINTS