| Tag | Content |
|---|
| CPLM ID | CPLM-006004 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium- and chloride-dependent GABA transporter 3 |
Protein Synonyms/Alias | GAT-3; Sodium- and chloride-dependent GABA transporter 4; GAT-4; Solute carrier family 6 member 11 |
Gene Name | Slc6a11 |
Gene Synonyms/Alias | Gabt3; Gabt4; Gat-4; Gat3; Gat4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 13 | ALPLGNGKAAEEARG | ubiquitination | [1] | | 581 | TLPEKLQKLTVPSAD | ubiquitination | [1] | | 590 | TVPSADLKMRGKLGA | ubiquitination | [1] | | 610 | TVNDCEAKVKGDGTI | ubiquitination | [1] | | 612 | NDCEAKVKGDGTISA | ubiquitination | [1] | | 623 | TISAITEKETHF*** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine. |
Sequence Annotation | CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
CARBOHYD 185 185 N-linked (GlcNAc...) (Potential).
CARBOHYD 193 193 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 627 AA |
Protein Sequence | MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN KVEFVLSVAG 60
EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF LETALGQFTS EGGITCWRRV 120
CPLFEGIGYA TQVIEAHLNV YYIIILAWAI FYLSNCFTTE LPWATCGHEW NTEKCVEFQK 180
LNFSNYSHVS LQNATSPVME FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK 240
GTKSTGKVVY VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 300
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV LGFMAYEQGV 360
PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF LGLDSQFVCV ESLVTAVVDM 420
YPKVFRRGYR RELLILALSI ISYFLGLVML TEGGMYIFQL FDSYAASGMC LLFVAIFECV 480
CIGWVYGSNR FYDNIEDMIG YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT 540
YPAWGYGIGW LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 600
TVTVNDCEAK VKGDGTISAI TEKETHF 627 |
Gene Ontology | GO:0042995; C:cell projection; IEA:Compara. GO:0005737; C:cytoplasm; IEA:Compara. GO:0005887; C:integral to plasma membrane; IEA:InterPro. GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:Compara. GO:0042165; F:neurotransmitter binding; IEA:Compara. GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. GO:0007420; P:brain development; IEA:Compara. GO:0042493; P:response to drug; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |