UniProt Accession

 CDK16_HUMAN; Q00536; A8K280; B7Z7C8; J3KN74; J3KQP7 

Genbank Protein ID

 X66363; BT006827; AK290145; AK301832; AL096791; AL513366; CH471164; CH471164; BC001048; BC015607 

Genbank Nucleotide ID

 CAA47006.1; AAP35473.1; BAF82834.1; BAH13564.1; CAD20055.1; EAW59295.1; EAW59297.1; AAH01048.1; AAH15607.1 

Protein Name

 Cyclin-dependent kinase 16 

Protein Synonyms/Alias

 Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1 

Gene Name

 CDK16 

Gene Synonyms/Alias

 PCTAIRE1; PCTK1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
133	LPEGYLEKLTLNSPI	ubiquitination	[1]
143	LNSPIFDKPLSRRLR	ubiquitination	[1]
167	GKLETYIKLDKLGEG	ubiquitination	[1]
194	TDNLVALKEIRLEHE	ubiquitination	[1]
455	SLGERIHKLPDTTSI	ubiquitination	[1]
466	TTSIFALKEIQLQKE	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser- 336' (in vitro). 

Sequence Annotation

 DOMAIN 165 446 Protein kinase.
 NP_BIND 171 179 ATP (By similarity).
 ACT_SITE 286 286 Proton acceptor (By similarity).
 BINDING 194 194 ATP (Probable).
 MOD_RES 12 12 Phosphoserine; by BRSK2.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 78 78 Phosphoserine.
 MOD_RES 82 82 Phosphoserine.
 MOD_RES 95 95 Phosphoserine; by CDK5.
 MOD_RES 110 110 Phosphoserine (By similarity).
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 155 155 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Differentiation; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Synapse; Synaptosome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 496 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:UniProtKB.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0006887; P:exocytosis; ISS:UniProtKB.
 GO:0030252; P:growth hormone secretion; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:UniProtKB.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS