CPLM-014376

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014376

UniProt Accession

ITA7_MOUSE; Q61738; O88731; O88732; P70350; Q61737; Q61741

Genbank Protein ID

L23423; Y12380; Y12383; Y12384; Y12385; Y12386; Y12387; Y12388; Y12389; Y12390; Y12382; L23422; Y12380; Y12383; Y12384; Y12385; Y12386; Y12387; Y12388; Y12389; Y12390; Y12381; Y12382; U60419; L23421; L16544

Genbank Nucleotide ID

AAA16600.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; CAA73023.1; AAA16599.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; CAA73024.1; AAC52772.1; AAA16598.1

Protein Name

Integrin alpha-7

Protein Synonyms/Alias

Integrin alpha-7 heavy chain; Integrin alpha-7 light chain

Gene Name

Itga7

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
1124	VPQYHAVKIPREDRQ	ubiquitination	[1]
1137	RQQFKEEKTGTIQRS	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity).

Sequence Annotation

REPEAT 38 103 FG-GAP 1.
REPEAT 110 175 FG-GAP 2.
REPEAT 185 238 FG-GAP 3.
REPEAT 292 350 FG-GAP 4.
REPEAT 351 411 FG-GAP 5.
REPEAT 412 467 FG-GAP 6.
REPEAT 471 530 FG-GAP 7.
REPEAT 1155 1158 1.
REPEAT 1163 1166 2.
REPEAT 1171 1174 3.
REGION 1155 1174 3 X 4 AA repeats of D-X-H-P.
MOTIF 1105 1109 GFFKR motif.
CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
CARBOHYD 784 784 N-linked (GlcNAc...) (Potential).
CARBOHYD 988 988 N-linked (GlcNAc...) (Potential).
CARBOHYD 1023 1023 N-linked (GlcNAc...).
CARBOHYD 1043 1043 N-linked (GlcNAc...) (Potential).
DISULFID 94 103 By similarity.
DISULFID 140 163 By similarity.
DISULFID 184 197 By similarity.
DISULFID 539 546 By similarity.
DISULFID 552 615 By similarity.
DISULFID 681 687 By similarity.
DISULFID 781 792 By similarity.
DISULFID 939 993 Interchain (between heavy and light
DISULFID 999 1004 By similarity.

Keyword

ADP-ribosylation; Alternative splicing; Calcium; Cell adhesion; Cell shape; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1179 AA

Protein Sequence

MARIPRCDFL RPPGIYYLIT SLLAGLFLPP AIAFNLDVMG AIRKEGEPGS LFGFSVALHR 60
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDR GANVQKESKE 120
NQWLGVSVRS QGAGGKIVTC AHRYESRQRV DQALETRDVI GRCFVLSQDL AIRDELDGGE 180
WKFCEGRPQG HEQFGFCQQG TAATFSPDSH YLVFGAPGTY NWKGTARVEL CAQGSPDLAH 240
LDDGPYEAGG EKEQDPRLIP VPANSYLGLL FVTNIDSSDP DQLVYKTLDP ADRLTGPAGD 300
LTLNSYLGFS IDSGKGLMRS EELSFVAGAP RANHKGAVVI LRKDSATRLI PEVVLSGERL 360
TSGFGYSLAV TDLNNDGWAD LIVGAPYFFE RQEELGGAVY VYMNQGGHWA DISPLRICGS 420
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVVKPS QVLEGEAVGI 480
KSFGYSLSGG LDVDGNHYPD LLVGSLADTA ALFRARPVLH VSQEIFIDPR AIDLEQPNCA 540
DGRLVCVDIK ICFSYVAVPS SYSPSVALDY MLDGDTDRRL RGQVPRVTFL SRGLDDLRHQ 600
SSGTVWLKHQ HDRVCGDTVF QLQENVKDKL RAIVVTLSYG LRTPPLGRQA PGQELPTVAP 660
ILNAHQPSTQ RTEIHFLKQG CGQDKICQSN LQLERYQFCS RISDTEFQAL PMDLDGRTAL 720
FALSGQPFIG LELTVTNLPS DPSRPQADGD DAHEAQLLVT LPASLRYSGV RALDSVEKPL 780
CLSNDSASHV ECELGNPMKR GAQVTFYLIL STSGITIETT ELEVKLLLAT ISEQELDPVS 840
VRAHVFIELP LSISGVATPQ QLFFSGEVKG ESAMRSEREL GRKVKYEVTV SNQGQSLNTL 900
GSANLNIMWP HEIANGKWLL YPMRVELEGG QGPGKRGICS PRPNILQLDV DSRDRRRREL 960
GQPEPQEPPE KVEPSTSWWP VSSAEKRNMT LDCPRTAKCV VFSCPLYSFD RAAVLHVWGR 1020
LWNSTFLEEY MAVKSLEVIV RANITVKSSI KNLLLRDAST VIPVMVYLDP MAVVVEGVPW 1080
WVILLGVLAG LLVLALLVLL LWKLGFFKRA KHPEATVPQY HAVKIPREDR QQFKEEKTGT 1140
IQRSNWGNSQ WEGSDAHPIL AADWHPELGP DGHPVPATA 1179

Gene Ontology

GO:0005737; C:cytoplasm; IDA:MGI.
GO:0008305; C:integrin complex; IEA:InterPro.
GO:0043236; F:laminin binding; IMP:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
GO:0007155; P:cell adhesion; IMP:MGI.
GO:0016477; P:cell migration; IMP:MGI.
GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.

Interpro

IPR013519; Int_alpha_beta-p.
IPR000413; Integrin_alpha.
IPR013649; Integrin_alpha-2.
IPR018184; Integrin_alpha_C_CS.

Pfam

PF08441; Integrin_alpha2

SMART

SM00191; Int_alpha

PROSITE

PS51470; FG_GAP
PS00242; INTEGRIN_ALPHA

PRINTS

PR01185; INTEGRINA.