CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002219
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arginase-1 
Protein Synonyms/Alias
 Liver-type arginase; Type I arginase 
Gene Name
 ARG1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191PGEHYILKTLGIKYFacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REGION 126 130 Substrate binding.
 REGION 137 139 Substrate binding.
 METAL 101 101 Manganese 1.
 METAL 124 124 Manganese 1.
 METAL 124 124 Manganese 2.
 METAL 126 126 Manganese 2.
 METAL 128 128 Manganese 1.
 METAL 232 232 Manganese 1.
 METAL 232 232 Manganese 2.
 METAL 234 234 Manganese 2.
 BINDING 183 183 Substrate.
 MOD_RES 230 230 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Arginine metabolism; Complete proteome; Cytoplasm; Disease mutation; Hydrolase; Manganese; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Urea cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 322 AA 
Protein Sequence
MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN 60
DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV 120
IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR 180
DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF 240
TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT 300
LACFGLAREG NHKPIDYLNP PK 322 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0004053; F:arginase activity; EXP:Reactome.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0006527; P:arginine catabolic process; TAS:ProtInc.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Compara.
 GO:0071377; P:cellular response to glucagon stimulus; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0032964; P:collagen biosynthetic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0060056; P:mammary gland involution; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0070207; P:protein homotrimerization; IEA:Compara.
 GO:0010963; P:regulation of L-arginine import; IEA:Compara.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009635; P:response to herbicide; IEA:Compara.
 GO:0010042; P:response to manganese ion; IEA:Compara.
 GO:0051597; P:response to methylmercury; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0033189; P:response to vitamin A; IEA:Compara.
 GO:0033197; P:response to vitamin E; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0000050; P:urea cycle; TAS:Reactome. 
Interpro
 IPR014033; Arginase.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 
Pfam
 PF00491; Arginase 
SMART
  
PROSITE
 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 
PRINTS
 PR00116; ARGINASE.