UniProt Accession

 MIEN1_HUMAN; Q9BRT3 

Genbank Protein ID

 AY508814; AF490253; AC079199; BC006006 

Genbank Nucleotide ID

 AAR92035.1; AAO85461.1; AAH06006.1 

Protein Name

 Migration and invasion enhancer 1 

Protein Synonyms/Alias

 HBV X-transactivated gene 4 protein; HBV XAg-transactivated protein 4; Protein C35 

Gene Name

 MIEN1 

Gene Synonyms/Alias

 C17orf37; RDX12; XTP4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	NGGFPYEKDLIEAIR	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 LIPID 112 112 S-geranylgeranyl cysteine.
 DISULFID 30 33 Redox-active.  

Keyword

 3D-structure; Acetylation; Apoptosis; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Lipoprotein; Membrane; Prenylation; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031235; C:intrinsic to internal side of plasma membrane; IDA:UniProtKB.
 GO:0008430; F:selenium binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB. 

Interpro

 IPR011893; Selenoprotein_Rdx-typ.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10262; Rdx 

SMART

  

PROSITE

  

PRINTS