CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021328
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein P1 
Protein Synonyms/Alias
  
Gene Name
 FOXP1 
Gene Synonyms/Alias
 HSPC215 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
362HVKSTEPKAAPQPLNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity). 
Sequence Annotation
 ZN_FING 306 331 C2H2-type.
 DNA_BIND 465 555 Fork-head.
 REGION 348 369 Leucine-zipper.
 REGION 382 386 CTBP1-binding (By similarity).  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Mental retardation; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
CRSTLVDPKN SARASQKQPE PIYSKKTEIQ RQTVRAPFAK LFIFSALQVA RQLLLQQQQQ 60
QQVSGLKSPK RNDKQPALQV PVSVAMMTPQ VITPQQMQQI LQQQVLSPQQ LQVLLQQQQA 120
LMLQQQQLQE FYKKQQEQLQ LQLLQQQHAG KQPKEQQQVA TQQLAFQQQL LQMQQLQQQH 180
LLSLQRQGLL TIQPGQPALP LQPLAQGMIP TELQQLWKEV TSAHTAEETT GNNHSSLDLT 240
TTCVSSSAPS KTSLIMNPHA STNGQLSVHT PKRESLSHEE HPHSHPLYGH GVCKWPGCEA 300
VCEDFQSFLK HLNSEHALDD RSTAQCRVQM QVVQQLELQL AKDKERLQAM MTHLHVKSTE 360
PKAAPQPLNL VSSVTLSKSA SEASPQSLPH TPTTPTAPLT PVTQGPSVIT TTSMHTVGPI 420
RRRYSDKYNV PISSADIAQN QEFYKNAEVR PPFTYASLIR QAILESPEKQ LTLNEIYNWF 480
TRMFAYFRRN AATWKNAVRH NLSLHKCFVR VENVKGAVWT VDEVEFQKRR PQKISGNPSL 540
IKNMQSSHAY CTPLNAALQA SMAENSIPLY TTASMGNPTL GNLASAIREE LNGAMEHTNS 600
NESDSSPGRS PMQAVHPVHV KEEPLDPEEA EGPLSLVTTA NHSPDFDHDR DYEDEPVNED 660
ME 662 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; IBA:RefGenome.
 GO:0042803; F:protein homodimerization activity; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0055007; P:cardiac muscle cell differentiation; IBA:RefGenome.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0033152; P:immunoglobulin V(D)J recombination; IBA:RefGenome.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IBA:RefGenome.
 GO:0002639; P:positive regulation of immunoglobulin production; IBA:RefGenome.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IBA:RefGenome.
 GO:0002329; P:pre-B cell differentiation; IBA:RefGenome.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0007519; P:skeletal muscle tissue development; IBA:RefGenome.
 GO:0048745; P:smooth muscle tissue development; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH
 SM00355; ZnF_C2H2 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS
 PR00053; FORKHEAD.