CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WW domain-binding protein 2 
Protein Synonyms/Alias
 cDNA FLJ59459, highly similar to WW domain-binding protein 2 
Gene Name
 WBP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40YRVIFLSKGKDAMQSubiquitination[1]
42VIFLSKGKDAMQSFMubiquitination[1, 2]
61LMKDCEIKQPVFGANubiquitination[1]
71VFGANYIKGTVKAEAubiquitination[1]
236PYYPPEDKKTQ****ubiquitination[2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 239 AA 
Protein Sequence
MSYDHVELTF NDMKNVPEAF KGTKKGTVYL TPYRVIFLSK GKDAMQSFMM PFYLMKDCEI 60
KQPVFGANYI KGTVKAEAGG GWEGSASYKL TFTAGGAIEF GQRMLQVASQ ASRGEVPSGA 120
YGYSYMPSGA YVYPPPVANG MYPCPPGYPY PPPPPEFYPG PPMMDGAMGY VQPPPPPYPG 180
PMEPPVSGPD VPSTPAAEAK AAEAAASAYY NPGNPHNVYM PTSQPPPPPY YPPEDKKTQ 239 
Gene Ontology
  
Interpro
 IPR004182; GRAM.
 IPR018826; WW-domain-binding. 
Pfam
 PF02893; GRAM
 PF10349; WWbp 
SMART
  
PROSITE
  
PRINTS