CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Drebrin 
Protein Synonyms/Alias
 Developmentally-regulated brain protein 
Gene Name
 Dbn1 
Gene Synonyms/Alias
 Drba 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
252EEAKRRLKEQSIFGDacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively (By similarity). 
Sequence Annotation
 DOMAIN 3 134 ADF-H.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 134 134 Phosphoserine.
 MOD_RES 141 141 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 344 344 Phosphoserine.
 MOD_RES 379 379 Phosphothreonine (By similarity).
 MOD_RES 383 383 Phosphothreonine (By similarity).
 MOD_RES 385 385 Phosphoserine.
 MOD_RES 387 387 Phosphoserine (By similarity).
 MOD_RES 390 390 Phosphoserine.
 MOD_RES 394 394 Phosphothreonine.  
Keyword
 Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN 60
QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS 120
VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF 180
WEQAKKEEEL RKEEERKKAL DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ 240
SLEAEEAKRR LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV 300
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF PYITCHRTPN 360
LSSSLPCSHL DSHRRMAPTP IPTRSPSDSS TASTPIAEQI ERALDEVTSS QPPPPPPPPP 420
PTQEAQETTP SLDEELSKEA KVTAAPEVWA GCAAEPPQAQ EPPLLQSSPL EDSMCTESPE 480
QAALAAPAEP AASVTSVADV HAADTIETTT ATTDTTIANN VTPAAASLID LWPGNGEEAS 540
TLQAEPRVPT PPSGAEASLA EVPLLNEAAQ EPLPPVGEGC ANLLNFDELP EPPATFCDPE 600
EEVGETLAAS QVLTMPSALE EVDQVLEQEL EPEPHLLTNG ETTQKEGTQA SEGYFSQSQE 660
EEFAQSEEPC AKVPPPVFYN KPPEIDITCW DADPVPEEEE GFEGGD 706 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005522; F:profilin binding; ISS:UniProtKB.
 GO:0007015; P:actin filament organization; IDA:MGI.
 GO:0010643; P:cell communication by chemical coupling; IMP:MGI.
 GO:0010644; P:cell communication by electrical coupling; IMP:MGI.
 GO:0048699; P:generation of neurons; IEP:DFLAT.
 GO:0032507; P:maintenance of protein location in cell; IMP:MGI.
 GO:0061351; P:neural precursor cell proliferation; IEP:DFLAT. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin. 
Pfam
 PF00241; Cofilin_ADF 
SMART
 SM00102; ADF 
PROSITE
 PS51263; ADF_H 
PRINTS