UniProt Accession

 PM34_HUMAN; O43808; A8KA59; Q5TFL0; Q9UGW8; Q9UGY7 

Genbank Protein ID

 Y12860; CR456577; AK292924; AL049764; Z98048; Z98048; AL049764; CH471095; BC005957; BC012998 

Genbank Nucleotide ID

 CAA73367.1; CAG30463.1; BAF85613.1; CAI20333.1; CAI20333.1; CAI20491.1; CAI20491.1; EAW60390.1; AAH05957.1; AAH12998.1 

Protein Name

 Peroxisomal membrane protein PMP34 

Protein Synonyms/Alias

 34 kDa peroxisomal membrane protein; Solute carrier family 25 member 17 

Gene Name

 SLC25A17 

Gene Synonyms/Alias

 PMP34 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	LRLQVDEKRKSKTTH	ubiquitination	[1]
130	WVVNTRLKLQGAKFR	ubiquitination	[1]
135	RLKLQGAKFRNEDIV	ubiquitination	[1]
147	DIVPTNYKGIIDAFH	ubiquitination	[1]
268	FGIMGLYKGLEAKLL	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. 

Sequence Annotation

 REPEAT 7 92 Solcar 1.
 REPEAT 99 192 Solcar 2.
 REPEAT 200 294 Solcar 3.
 REGION 1 147 Necessary for targeting to peroxisomes
 REGION 244 307 Necessary for targeting to peroxisomes
 MOTIF 190 199 Peroxisome localization signal.  

Keyword

 Complete proteome; Cytoplasm; Membrane; Peroxisome; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0005779; C:integral to peroxisomal membrane; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0015217; F:ADP transmembrane transporter activity; IDA:UniProtKB.
 GO:0080122; F:AMP transmembrane transporter activity; IDA:UniProtKB.
 GO:0005347; F:ATP transmembrane transporter activity; IGI:BHF-UCL.
 GO:0015228; F:coenzyme A transmembrane transporter activity; IDA:UniProtKB.
 GO:0015230; F:FAD transmembrane transporter activity; IDA:UniProtKB.
 GO:0044610; F:FMN transmembrane transporter activity; IDA:UniProtKB.
 GO:0051724; F:NAD transporter activity; IDA:UniProtKB.
 GO:0001561; P:fatty acid alpha-oxidation; TAS:Reactome.
 GO:0006635; P:fatty acid beta-oxidation; IGI:BHF-UCL.
 GO:0015908; P:fatty acid transport; IGI:BHF-UCL. 

Interpro

 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00926; MITOCARRIER.