CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 60S ribosomal protein L13a 
Protein Synonyms/Alias
  
Gene Name
 Rpl13a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
245RLAAIVAKQVLLGRKacetylation[1]
273NFYRNKLKYLAFLRKacetylation[1]
273NFYRNKLKYLAFLRKubiquitination[2]
323QAALERLKVLDGIPPubiquitination[2]
334GIPPPYDKKKRMVVPubiquitination[2]
345MVVPAALKVVRLKPTubiquitination[2]
354VRLKPTRKFAYLGRLubiquitination[2]
379VTATLEEKRKEKAKMubiquitination[2]
408AEKNVEKKICKFTEVubiquitination[2]
411NVEKKICKFTEVLKTacetylation[3, 4]
411NVEKKICKFTEVLKTsuccinylation[3]
411NVEKKICKFTEVLKTubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MTVLAPAWSP NSSLLLLLLL LSPCLRGTPD CYFSHSPISS NFKVKFRELT DHLLKDYPVT 60
VAVNLQDEKH CKALWSLFLA QRWIEQLKTV AGSKMQTLLE DVNTEIHFVT SCTFQPLPEC 120
LRFVQTNISH LLKDTCTQLL ALKPCIGKAC QNFSRCLEVQ CQPDSSTLLP PRSPIALEAT 180
ELPEPRPRQL LLLLLLLLPL TLVLLAAAWG LRWQRARRRG ELHPGVLVLD GRGHLLGRLA 240
AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF 300
WRTVRGMLPH KTKRGQAALE RLKVLDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR 360
LAHEVGWKYQ AVTATLEEKR KEKAKMHYRK KKQILRLRKQ AEKNVEKKIC KFTEVLKTNG 420
LLV 423 
Gene Ontology
 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR009079; 4_helix_cytokine-like_core.
 IPR012351; 4_helix_cytokine_core.
 IPR004213; Flt3_lig.
 IPR005822; Ribosomal_L13.
 IPR023563; Ribosomal_L13_CS.
 IPR023564; Ribosomal_L13_dom.
 IPR005755; Ribosomal_L13_euk/arc. 
Pfam
 PF02947; Flt3_lig
 PF00572; Ribosomal_L13 
SMART
  
PROSITE
 PS00783; RIBOSOMAL_L13 
PRINTS