CPLM-009353

Genbank Nucleotide ID

V-type proton ATPase subunit d 1

Protein Synonyms/Alias

V-ATPase subunit d 1; 32 kDa accessory protein; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; p39; Vacuolar proton pump subunit d 1

Homo sapiens (Human)

Position	Peptide	Type	References
265	ADDYEQVKNVADYYP	ubiquitination	[1, 2, 3, 4]
275	ADYYPEYKLLFEGAG	ubiquitination	[1, 2, 4]
288	AGSNPGDKTLEDRFF	ubiquitination	[1, 2]
300	RFFEHEVKLNKLAFL	ubiquitination	[2]
343	IAQRHRAKIDNYIPI	ubiquitination	[2, 3, 4]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).

MOD_RES 270 270 Phosphotyrosine (By similarity).
MOD_RES 283 283 Phosphoserine (By similarity).

Cilium biogenesis/degradation; Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016324; C:apical plasma membrane; IEA:Compara.
GO:0043679; C:axon terminus; IEA:Compara.
GO:0005769; C:early endosome; IEA:Compara.
GO:0010008; C:endosome membrane; TAS:Reactome.
GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
GO:0008021; C:synaptic vesicle; IEA:Compara.
GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IDA:UniProtKB.
GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Compara.
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
GO:0007420; P:brain development; IEA:Compara.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0042384; P:cilium assembly; ISS:UniProtKB.
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
GO:0051701; P:interaction with host; TAS:Reactome.
GO:0090382; P:phagosome maturation; TAS:Reactome.
GO:0015992; P:proton transport; NAS:UniProtKB.
GO:0033572; P:transferrin transport; TAS:Reactome.
GO:0055085; P:transmembrane transport; TAS:Reactome.

IPR002843; ATPase_V0-cplx_csu/dsu.
IPR016727; ATPase_V0-cplx_dsu.

PF01992; vATP-synt_AC39