CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004473
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolactin receptor 
Protein Synonyms/Alias
 PRL-R 
Gene Name
 PRLR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
357LKSYRPRKISSQGRLmethylation[1]
369GRLAVFTKATLTTVQmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. 
Sequence Annotation
 DOMAIN 27 121 Fibronectin type-III 1.
 DOMAIN 127 227 Fibronectin type-III 2.
 MOTIF 215 219 WSXWS motif.
 MOTIF 267 275 Box 1 motif.
 METAL 211 211 Zinc.
 METAL 212 212 Zinc.
 CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 233 233 N-linked (GlcNAc...) (Potential).
 DISULFID 36 46
 DISULFID 75 86  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 60
SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 120
VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 180
EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 240
VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 300
FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGDPL MLGASHYKNL KSYRPRKISS 360
QGRLAVFTKA TLTTVQ 376 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0031904; C:endosome lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042978; F:ornithine decarboxylase activator activity; NAS:UniProtKB.
 GO:0017046; F:peptide hormone binding; IPI:BHF-UCL.
 GO:0004925; F:prolactin receptor activity; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; NAS:UniProtKB.
 GO:0042977; P:activation of JAK2 kinase activity; NAS:UniProtKB.
 GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; IDA:UniProtKB.
 GO:0007566; P:embryo implantation; TAS:ProtInc.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0007595; P:lactation; NAS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; NAS:UniProtKB.
 GO:0006694; P:steroid biosynthetic process; NAS:UniProtKB.
 GO:0042110; P:T cell activation; NAS:UniProtKB. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR015152; Growth/epo_recpt_lig-bind.
 IPR013783; Ig-like_fold.
 IPR003528; Long_hematopoietin_rcpt_CS. 
Pfam
 PF09067; EpoR_lig-bind 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01352; HEMATOPO_REC_L_F1 
PRINTS