CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022532
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LisH domain and HEAT repeat-containing protein KIAA1468 
Protein Synonyms/Alias
  
Gene Name
 KIAA1468 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
877GKIFTNTKVKPQFQEubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 255 287 LisH.
 REPEAT 601 639 HEAT 1.
 REPEAT 640 679 HEAT 2.
 REPEAT 1004 1042 HEAT 3.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 32 32 Phosphothreonine (By similarity).
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 180 180 Phosphoserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 183 183 Phosphothreonine.
 MOD_RES 186 186 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1216 AA 
Protein Sequence
MAAMAPGGSG SGGGVNPFLS DSDEDDDEVA ATEERRAVLR LGAGSGLDPG SAGSLSPQDP 60
VALGSSARPG LPGEASAAAV ALGGTGETPA RLSIDAIAAQ LLRDQYLLTA LELHTELLES 120
GRELPRLRDY FSNPGNFERQ SGTPPGMGAP GVPGAAGVGG AGGREPSTAS GGGQLNRAGS 180
ISTLDSLDFA RYSDDGNRET DEKVAVLEFE LRKAKETIQA LRANLTKAAE HEVPLQERKN 240
YKSSPEIQEP IKPLEKRALN FLVNEFLLKN NYKLTSITFS DENDDQDFEL WDDVGLNIPK 300
PPDLLQLYRD FGNHQVTGKD LVDVASGVEE DELEALTPII SNLPPTLETP QPAENSMLVQ 360
KLEDKISLLN SEKWSLMEQI RRLKSEMDFL KNEHFAIPAV CDSVQPPLDQ LPHKDSEDSG 420
QHPDVNSSDK GKNTDIHLSI SDEADSTIPK ENSPNSFPRR EREGMPPSSL SSKKTVHFDK 480
PNRKLSPAFH QALLSFCRMS ADSRLGYEVS RIADSEKSVM LMLGRCLPHI VPNVLLAKRE 540
ELIPLILCTA CLHPEPKERD QLLHILFNLI KRPDDEQRQM ILTGCVAFAR HVGPTRVEAE 600
LLPQCWEQIN HKYPERRLLV AESCGALAPY LPKEIRSSLV LSMLQQMLME DKADLVREAV 660
IKSLGIIMGY IDDPDKYHQG FELLLSALGD PSERVVSATH QVFLPAYAAW TTELGNLQSH 720
LILTLLNKIE KLLREGEHGL DEHKLHMYLS ALQSLIPSLF ALVLQNAPFS SKAKLHGEVP 780
QIEVTRFPRP MSPLQDVSTI IGSREQLAVL LQLYDYQLEQ EGTTGWESLL WVVNQLLPQL 840
IEIVGKINVT STACVHEFSR FFWRLCRTFG KIFTNTKVKP QFQEILRLSE ENIDSSAGNG 900
VLTKATVPIY ATGVLTCYIQ IKEYLHIHNE ISWEWDPSLN TKCVSYTHYT HSLKEEDRKL 960
LVGFLEDVMT LLSLSHAPLD SLKASFVELG ANPAYHELLL TVLWYGVVHT SALVRCTAAR 1020
MFELLVKGVN ETLVAQRVVP ALITLSSDPE ISVRIATIPA FGTIMETVIQ RELLERVKMQ 1080
LASFLEDPQY QDQHSLHTEI IKTFGRVGPN AEPRFRDEFV IPHLHKLALV NNLQIVDSKR 1140
LDIATHLFEA YSALSCCFIS EDLMVNHFLP GLRCLRTDME HLSPEHEVIL SSMIKECEQK 1200
VENKTVQEPQ GSMSIAASLV SEDTKTKFLN KMGQLTTSGA MLANVFQRKK 1250 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR021133; HEAT_type_2.
 IPR006594; LisH_dimerisation. 
Pfam
  
SMART
 SM00667; LisH 
PROSITE
 PS50077; HEAT_REPEAT
 PS50896; LISH 
PRINTS