UniProt Accession

 CP2C9_HUMAN; P11712; P11713; Q16756; Q16872; Q5VX92 

Genbank Protein ID

 AY341248; AY702706; AK289420; AL359672; CH471066; BC125054; D00173; M15331; M21939; M21940; S46963 

Genbank Nucleotide ID

 AAP88931.1; AAT94065.1; BAF82109.1; CAH71303.1; EAW50020.1; AAI25055.1; BAA00123.1; AAA52157.1; AAA52158.1; AAA52159.1; AAB23864.2 

Protein Name

 Cytochrome P450 2C9 

Protein Synonyms/Alias

 (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase 

Gene Name

 CYP2C9 

Gene Synonyms/Alias

 CYP2C10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
200	QFLNLMEKLNENIKI	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan. 

Sequence Annotation

 METAL 435 435 Iron (heme axial ligand).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0052741; F:(R)-limonene 6-monooxygenase activity; IEA:EC.
 GO:0018675; F:(S)-limonene 6-monooxygenase activity; IEA:EC.
 GO:0018676; F:(S)-limonene 7-monooxygenase activity; IEA:EC.
 GO:0034875; F:caffeine oxidase activity; IDA:BHF-UCL.
 GO:0008144; F:drug binding; IDA:BHF-UCL.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008395; F:steroid hydroxylase activity; IMP:BHF-UCL.
 GO:0019373; P:epoxygenase P450 pathway; TAS:Reactome.
 GO:0042738; P:exogenous drug catabolic process; IDA:BHF-UCL.
 GO:0016098; P:monoterpenoid metabolic process; IDA:BHF-UCL.
 GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
 GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.
 GO:0008202; P:steroid metabolic process; IMP:BHF-UCL.
 GO:0019627; P:urea metabolic process; IDA:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.