UniProt Accession

 A4D2F2_HUMAN; A4D2F2 

Genbank Protein ID

 AK290459; CH236958; CH471128; CH471128 

Genbank Nucleotide ID

 BAF83148.1; EAL23807.1; EAW61001.1; EAW61002.1 

Protein Name

 HUS1 checkpoint homolog (S. pombe) 

Protein Synonyms/Alias

 HUS1 checkpoint homolog (S. pombe), isoform CRA_a; cDNA FLJ76255, highly similar to Homo sapiens HUS1 checkpoint homolog (S. pombe) (HUS1), mRNA 

Gene Name

 HUS1 

Gene Synonyms/Alias

 hCG_17018; tcag7.704 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	VTHDIPIKVIPRKLW	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

  

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 280 AA 

Protein Sequence

Gene Ontology

 GO:0030896; C:checkpoint clamp complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0000077; P:DNA damage checkpoint; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0009411; P:response to UV; IEA:Compara. 

Interpro

 IPR016580; Cell_cycle_HUS1.
 IPR007150; Hus1/Mec3. 

Pfam

 PF04005; Hus1 

SMART

  

PROSITE

  

PRINTS