UniProt Accession

 CTNB1_MOUSE; Q02248; Q922W1; Q9D335 

Genbank Protein ID

 M90364; AK035311; AK018515; BC006739; BC048153; BC053065 

Genbank Nucleotide ID

 AAA37280.1; BAC29027.1; BAB31250.1; AAH06739.1; AAH48153.1; AAH53065.1 

Protein Name

 Catenin beta-1 

Protein Synonyms/Alias

 Beta-catenin 

Gene Name

 Ctnnb1 

Gene Synonyms/Alias

 Catnb 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	MAMEPDRKAAVSHWQ	ubiquitination	[1]
133	AEPSQMLKHAVVNLI	ubiquitination	[1]
158	RAIPELTKLLNDEDQ	ubiquitination	[1]
170	EDQVVVNKAAVMVHQ	ubiquitination	[1]
233	EGLLAIFKSGGIPAL	ubiquitination	[1]
671	EDKPQDYKKRLSVEL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). 

Sequence Annotation

 REPEAT 151 191 ARM 1.
 REPEAT 193 234 ARM 2.
 REPEAT 235 276 ARM 3.
 REPEAT 277 318 ARM 4.
 REPEAT 319 360 ARM 5.
 REPEAT 361 389 ARM 6.
 REPEAT 400 441 ARM 7.
 REPEAT 442 484 ARM 8.
 REPEAT 489 530 ARM 9.
 REPEAT 531 571 ARM 10.
 REPEAT 594 636 ARM 11.
 REPEAT 637 666 ARM 12.
 REGION 1 23 Interaction with VCL.
 REGION 772 781 Interaction with SCRIB.
 MOD_RES 23 23 Phosphoserine; by GSK3-beta (By
 MOD_RES 29 29 Phosphoserine; by GSK3-beta (By
 MOD_RES 33 33 Phosphoserine; by GSK3-beta and HIPK2.
 MOD_RES 37 37 Phosphoserine; by GSK3-beta and HIPK2.
 MOD_RES 41 41 Phosphothreonine; by GSK3-beta (By
 MOD_RES 45 45 Phosphoserine (By similarity).
 MOD_RES 64 64 Phosphotyrosine; by PTK6 (By similarity).
 MOD_RES 86 86 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 142 142 Phosphotyrosine; by FYN and PTK6.
 MOD_RES 191 191 Phosphoserine; by CDK5 (By similarity).
 MOD_RES 246 246 Phosphoserine; by CDK5 (By similarity).
 MOD_RES 331 331 Phosphotyrosine (By similarity).
 MOD_RES 551 551 Phosphothreonine.
 MOD_RES 552 552 Phosphoserine; by AMPK.
 MOD_RES 556 556 Phosphothreonine.
 MOD_RES 619 619 S-nitrosocysteine.
 MOD_RES 654 654 Phosphotyrosine.
 MOD_RES 675 675 Phosphoserine.  

Keyword

 3D-structure; Activator; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; S-nitrosylation; Transcription; Transcription regulation; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 781 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0030877; C:beta-catenin destruction complex; ISS:UniProtKB.
 GO:0070369; C:beta-catenin-TCF7L2 complex; ISS:UniProtKB.
 GO:0016342; C:catenin complex; ISS:UniProtKB.
 GO:0005938; C:cell cortex; ISS:UniProtKB.
 GO:0005924; C:cell-substrate adherens junction; ISS:UniProtKB.
 GO:0005813; C:centrosome; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0043198; C:dendritic shaft; IBA:RefGenome.
 GO:0030057; C:desmosome; IBA:RefGenome.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0009898; C:internal side of plasma membrane; IBA:RefGenome.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0031528; C:microvillus membrane; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
 GO:0034750; C:Scrib-APC-beta-catenin complex; IDA:BHF-UCL.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005915; C:zonula adherens; IBA:RefGenome.
 GO:0045294; F:alpha-catenin binding; IDA:MGI.
 GO:0045296; F:cadherin binding; ISO:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003690; F:double-stranded DNA binding; IDA:MGI.
 GO:0019901; F:protein kinase binding; IBA:RefGenome.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0005198; F:structural molecule activity; IBA:RefGenome.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0034333; P:adherens junction assembly; ISS:UniProtKB.
 GO:0009948; P:anterior/posterior axis specification; IMP:MGI.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0045453; P:bone resorption; IMP:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
 GO:0044336; P:canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process; IEA:Compara.
 GO:0061324; P:canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; IMP:BHF-UCL.
 GO:0044334; P:canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
 GO:0060038; P:cardiac muscle cell proliferation; TAS:DFLAT.
 GO:0001708; P:cell fate specification; IMP:MGI.
 GO:0048469; P:cell maturation; IDA:MGI.
 GO:0016337; P:cell-cell adhesion; IMP:MGI.
 GO:0007160; P:cell-matrix adhesion; IMP:MGI.
 GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
 GO:0071681; P:cellular response to indole-3-methanol; ISS:UniProtKB.
 GO:0022009; P:central nervous system vasculogenesis; IMP:MGI.
 GO:0060982; P:coronary artery morphogenesis; TAS:DFLAT.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; IBA:RefGenome.
 GO:0009950; P:dorsal/ventral axis specification; IMP:MGI.
 GO:0007398; P:ectoderm development; IMP:MGI.
 GO:0000578; P:embryonic axis specification; IDA:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
 GO:0048617; P:embryonic foregut morphogenesis; IMP:MGI.
 GO:0035115; P:embryonic forelimb morphogenesis; IDA:MGI.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
 GO:0036023; P:embryonic skeletal limb joint morphogenesis; IGI:BHF-UCL.
 GO:0001711; P:endodermal cell fate commitment; IMP:MGI.
 GO:0061154; P:endothelial tube morphogenesis; ISS:UniProtKB.
 GO:0060983; P:epicardium-derived cardiac vascular smooth muscle cell differentiation; TAS:DFLAT.
 GO:0060742; P:epithelial cell differentiation involved in prostate gland development; IMP:MGI.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0061198; P:fungiform papilla formation; IMP:MGI.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0035112; P:genitalia morphogenesis; IMP:MGI.
 GO:0007403; P:glial cell fate determination; IDA:MGI.
 GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
 GO:0060789; P:hair follicle placode formation; IMP:MGI.
 GO:0030902; P:hindbrain development; IBA:RefGenome.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0002089; P:lens morphogenesis in camera-type eye; IMP:MGI.
 GO:0001889; P:liver development; IBA:RefGenome.
 GO:0060479; P:lung cell differentiation; IMP:MGI.
 GO:0060492; P:lung induction; IMP:MGI.
 GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.
 GO:0030539; P:male genitalia development; IMP:MGI.
 GO:0060916; P:mesenchymal cell proliferation involved in lung development; IMP:MGI.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IDA:MGI.
 GO:0072132; P:mesenchyme morphogenesis; TAS:DFLAT.
 GO:0007494; P:midgut development; IEA:Compara.
 GO:0045445; P:myoblast differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IGI:MGI.
 GO:0003136; P:negative regulation of heart induction by canonical Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.
 GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.
 GO:0033234; P:negative regulation of protein sumoylation; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0072079; P:nephron tubule formation; IMP:MGI.
 GO:0001840; P:neural plate development; IDA:MGI.
 GO:0001764; P:neuron migration; IGI:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0048599; P:oocyte development; IGI:MGI.
 GO:0030316; P:osteoclast differentiation; IMP:MGI.
 GO:0060066; P:oviduct development; IMP:MGI.
 GO:0031016; P:pancreas development; IMP:MGI.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IMP:MGI.
 GO:2000017; P:positive regulation of determination of dorsal identity; IDA:MGI.
 GO:0045603; P:positive regulation of endothelial cell differentiation; IMP:MGI.
 GO:0060769; P:positive regulation of epithelial cell proliferation involved in prostate gland development; IMP:MGI.
 GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IMP:MGI.
 GO:0010909; P:positive regulation of heparan sulfate proteoglycan biosynthetic process; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI.
 GO:0043410; P:positive regulation of MAPK cascade; IGI:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
 GO:0002052; P:positive regulation of neuroblast proliferation; IGI:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
 GO:0009954; P:proximal/distal pattern formation; IMP:MGI.
 GO:0090279; P:regulation of calcium ion import; ISS:UniProtKB.
 GO:0030997; P:regulation of centriole-centriole cohesion; ISS:UniProtKB.
 GO:0070602; P:regulation of centromeric sister chromatid cohesion; IMP:BHF-UCL.
 GO:0031641; P:regulation of myelination; IMP:MGI.
 GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB.
 GO:2000008; P:regulation of protein localization to cell surface; ISS:UniProtKB.
 GO:0003266; P:regulation of secondary heart field cardioblast proliferation; IDA:MGI.
 GO:0048660; P:regulation of smooth muscle cell proliferation; ISS:UniProtKB.
 GO:0042129; P:regulation of T cell proliferation; IMP:MGI.
 GO:0072053; P:renal inner medulla development; IMP:MGI.
 GO:0072054; P:renal outer medulla development; IMP:MGI.
 GO:0072033; P:renal vesicle formation; IMP:MGI.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; ISS:UniProtKB.
 GO:0014010; P:Schwann cell proliferation; IBA:RefGenome.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0050808; P:synapse organization; IMP:MGI.
 GO:0048489; P:synaptic vesicle transport; IMP:MGI.
 GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
 GO:0048538; P:thymus development; IMP:MGI.
 GO:0060440; P:trachea formation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0003223; P:ventricular compact myocardium morphogenesis; TAS:DFLAT. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo.
 IPR013284; Beta-catenin. 

Pfam

 PF00514; Arm 

SMART

 SM00185; ARM 

PROSITE

 PS50176; ARM_REPEAT 

PRINTS

 PR01869; BCATNINFAMLY.