| Tag | Content |
|---|
| CPLM ID | CPLM-016624 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Two pore calcium channel protein 2 |
Protein Synonyms/Alias | Voltage-dependent calcium channel protein TPC2 |
Gene Name | Tpcn2 |
Gene Synonyms/Alias | Tpc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 357 | LQKTQLNKTHKQAIM | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Involved in smooth muscle contraction. |
Sequence Annotation | CARBOHYD 594 594 N-linked (GlcNAc...).
CARBOHYD 601 601 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Calcium; Calcium channel; Calcium transport; Complete proteome; Glycoprotein; Ion channel; Ion transport; Lysosome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 731 AA |
Protein Sequence | MAAEEQPLLG RDRGSGQVHS GAAADQELCI DQAVVFIEDA IKYRSIYHRM DAGSLWLYRW 60
YYSNVCQRVL GFIIFLILIL AFVEVPSSFT KTADVRYRSQ PWQPPCGLTE TIEAFCLLAF 120
LVDLSVKGYL VGQAQLQQNL WLLAYFMVLV VSVVDWIVSL SLACEEPLRM RRLLRPFFLL 180
QNSSMMKKTL KCIRWSLPEM ASVGLLLAIH LCLFTIIGML LFTIGEKDEA QDQERLAYFR 240
NLPEALTSLL VLLTTSNNPD VMIPAYTQNR AFALFFIVFT LIGSLFLMNL LTAIIYNQFR 300
GYLMKSLQTS LFRRRLGARA AYEVLASRAG PAGTTPELVG VNPETFLPVL QKTQLNKTHK 360
QAIMQKVQSY EGRPMLADEF QKLFDEVDKG LAKERPLKPQ YQSPFLQTAQ FIFSHHYFDY 420
LGNLVALGNL LSICVFLVLD SDLLPGERDD FVLGILDYIF ILYYLLELLF KVFALGLPGY 480
LSYHSNVFDG LLTIILLVSE ICTLAVYRLP HSGWKPEQYG PLSLWDMTRL MNTLIVFRFL 540
RIIPNIKPMA EVANTILGLI PNLRAFGGIL VVAYYVFAMI GINLFRGVIV PPGNSSLVPD 600
NNSAVCGSFE QLGYWPNNFD DFAAALITLW NVMVVNNWQV ILEAYKRYAG PWSMVYFVLW 660
WLVSSVIWIN LFLALLLENF LHRWDPQGHK QLLVGTKQMS VELMFRDILE EPKEEELMEK 720
LHKHPHLHLC R 731 |
Gene Ontology | GO:0010008; C:endosome membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IDA:UniProtKB. GO:0072345; F:NAADP-sensitive calcium-release channel activity; IDA:UniProtKB. GO:0005245; F:voltage-gated calcium channel activity; IMP:UniProtKB. GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB. GO:0006939; P:smooth muscle contraction; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |