UniProt Accession

 IF1AX_HUMAN; P47813; B2R5U5; Q0VGC2; Q5JPS5; Q5JPS6 

Genbank Protein ID

 L18960; AK312320; BT007064; AL732366; AL732366; BC000793; BC067851 

Genbank Nucleotide ID

 AAA19812.1; BAG35242.1; AAP35727.1; CAI40550.1; CAI40551.1; AAH00793.1; AAH67851.1 

Protein Name

 Eukaryotic translation initiation factor 1A, X-chromosomal 

Protein Synonyms/Alias

 eIF-1A X isoform; Eukaryotic translation initiation factor 4C; eIF-4C 

Gene Name

 EIF1AX 

Gene Synonyms/Alias

 EIF1A; EIF4C 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	QEYAQVIKMLGNGRL	ubiquitination	[1]
56	AMCFDGVKRLCHIRG	acetylation	[2]
56	AMCFDGVKRLCHIRG	ubiquitination	[1, 3, 4]
88	LRDYQDNKADVILKY	ubiquitination	[1]
94	NKADVILKYNADEAR	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. 

Sequence Annotation

 DOMAIN 22 96 S1-like.  

Keyword

 3D-structure; Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008135; F:translation factor activity, nucleic acid binding; TAS:ProtInc.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0006413; P:translational initiation; TAS:Reactome. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR006196; RNA-binding_domain_S1_IF1.
 IPR001253; TIF_eIF-1A.
 IPR018104; TIF_eIF-1A_CS. 

Pfam

 PF01176; eIF-1a 

SMART

 SM00652; eIF1a 

PROSITE

 PS01262; IF1A
 PS50832; S1_IF1_TYPE 

PRINTS