CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vacuolar protein sorting-associated protein 53 homolog 
Protein Synonyms/Alias
  
Gene Name
 VPS53 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102QALEEAQKAIQQLFGubiquitination[1]
110AIQQLFGKIKDIKDKacetylation[2, 3, 4]
110AIQQLFGKIKDIKDKubiquitination[5]
133KEITRDIKQLDHAKRubiquitination[5]
244DRRYAWIKRQLVDYEubiquitination[5]
253QLVDYEEKYGRMFPRubiquitination[5]
312NFEGFLAKRFSGCTLubiquitination[5]
326LTDGTLKKLESPPPSubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT LFPTEQSLAN 60
IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA QKAIQQLFGK IKDIKDKAEK 120
SEQMVKEITR DIKQLDHAKR HLTTSITTLN HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG 180
VMNVLEHFHK YMGIPQIRQL SERVKAAQTE LGQQILADFE EAFPSQGTKV AWLDKIDRRY 240
AWIKRQLVDY EEKYGRMFPR EWCMAERIAV EFCHVTRAEL AKIMRTRAKE IEVKLLLFAI 300
QRTTNFEGFL AKRFSGCTLT DGTLKKLESP PPSTNPFLED EPTPEMEELA TEKGDLDQPK 360
KPKAPDNPFH GIVSKCFEPH LYVYIESQDK NLGELIDRFV ADFKAQGPPK PNTDEGGAVL 420
PSCADLFVYY KKCMVQCSQL STGEPMIALT TIFQKYLREY AWKILSGNLP KTTTSSGGLT 480
ISSLLKEKEG SEVAKFTLEE LCLICNILST AEYCLATTQQ LEEKLKEKVD RHLQQYSAAG 540
SGSGCCL 547 
Gene Ontology
  
Interpro
 IPR007234; Vps53_N. 
Pfam
 PF04100; Vps53_N 
SMART
  
PROSITE
  
PRINTS