| Tag | Content |
|---|
| CPLM ID | CPLM-009564 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-aminobutyric acid receptor subunit alpha-1 |
Protein Synonyms/Alias | GABA(A) receptor subunit alpha-1 |
Gene Name | Gabra1 |
Gene Synonyms/Alias | Gabra-1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 390 | PGLATIAKSATIEPK | ubiquitination | [1] | | 400 | TIEPKEVKPETKPPE | ubiquitination | [1] | | 404 | KEVKPETKPPEPKKT | ubiquitination | [1] | | 410 | TKPPEPKKTFNSVSK | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Sequence Annotation | MOD_RES 367 367 Phosphotyrosine (By similarity).
MOD_RES 374 374 Phosphotyrosine (By similarity).
CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
DISULFID 165 179 By similarity. |
Keyword | Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 455 AA |
Protein Sequence | MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL 60
GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER LKFKGPMTVL RLNNLMASKI 120
WTPDTFFHNG KKSVAHNMTM PNKLLRITED GTLLYTMRLT VRAECPMHLE DFPMDAHACP 180
LKFGSYAYTR AEVVYEWTRE PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT 240
THFHLKRKIG YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 300
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP EKPKKVKDPL 360
IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK PETKPPEPKK TFNSVSKIDR 420
LSRIAFPLLF GIFNLVYWAT YLNREPQLKA PTPHQ 455 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; IDA:RGD. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0008503; F:benzodiazepine receptor activity; TAS:RGD. GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. GO:0008144; F:drug binding; IDA:RGD. GO:0004890; F:GABA-A receptor activity; TAS:RGD. GO:0005237; F:inhibitory extracellular ligand-gated ion channel activity; TAS:RGD. GO:0006821; P:chloride transport; TAS:RGD. GO:0007214; P:gamma-aminobutyric acid signaling pathway; TAS:RGD. GO:0051932; P:synaptic transmission, GABAergic; IDA:BHF-UCL. |
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