UniProt Accession

 OARD1_HUMAN; Q9Y530; A6NEK4; A8K4H4; Q96F23 

Genbank Protein ID

 AK290939; AK313361; AL031778; CH471081; BC011709 

Genbank Nucleotide ID

 BAF83628.1; BAG36161.1; CAI20285.1; EAX04011.1; AAH11709.1 

Protein Name

 O-acetyl-ADP-ribose deacetylase 1 

Protein Synonyms/Alias

  

Gene Name

 OARD1 

Gene Synonyms/Alias

 C6orf130 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	GSRITYVKGDLFACP	ubiquitination	[1, 2]
104	QKSLEAMKSHCLKNG	ubiquitination	[2]
109	AMKSHCLKNGVTDLS	ubiquitination	[3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. 

Sequence Annotation

 DOMAIN 2 152 Macro.
 REGION 119 125 Substrate binding.
 ACT_SITE 125 125 Proton acceptor.
 BINDING 21 21 Substrate; via amide nitrogen.
 BINDING 152 152 Substrate; via carbonyl oxygen.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 4 4 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Hydrolase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0019213; F:deacetylase activity; IDA:UniProtKB.
 GO:0001883; F:purine nucleoside binding; IDA:UniProtKB.
 GO:0042278; P:purine nucleoside metabolic process; IDA:UniProtKB. 

Interpro

 IPR002589; A1pp. 

Pfam

 PF01661; Macro 

SMART

  

PROSITE

 PS51154; MACRO 

PRINTS