CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028419
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adducin 1 (Alpha) 
Protein Synonyms/Alias
 Adducin 1 (Alpha), isoform CRA_e; Alpha-adducin 
Gene Name
 ADD1 
Gene Synonyms/Alias
 hCG_20629; RP11-520M5.1-003 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21PPTTAPHKERYFDRVubiquitination[1, 2]
55DFNMMEQKKRVSMILubiquitination[3]
140SDSIAYDKGEKLLRCacetylation[2]
140SDSIAYDKGEKLLRCubiquitination[1, 2, 3]
143IAYDKGEKLLRCKLAubiquitination[1]
148GEKLLRCKLAAFYRLubiquitination[1]
288EEKVLIQKNLGPKSKubiquitination[1]
348LVLLNPEKYKAKSRSubiquitination[1, 2, 3]
350LLNPEKYKAKSRSPGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 662 AA 
Protein Sequence
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 60
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS 120
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 180
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI 240
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 300
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV 360
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS 420
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KVWTNITHDH 480
VKPLLQSLSS GVCVPSCITN CLWTKEDGHR TSTSAVPNLF VPLNTNPKEV QEMRNKIREQ 540
NLQDIKTAGP QSQVLCGVVM DRSLVQGELV TASKAIIEKE YQPHVIVSTT GPNPFTTLTD 600
RELEEYRREV ERKQKGSEEN LDEAREQKEK SPPDQPAVPH PPPSTPIKLE EGDGCAREYL 660
LP 662 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:InterPro. 
Interpro
 IPR001303; Aldolase_II/adducin_N. 
Pfam
 PF00596; Aldolase_II 
SMART
 SM01007; Aldolase_II 
PROSITE
  
PRINTS