CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007407
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptotagmin-4 
Protein Synonyms/Alias
 Synaptotagmin IV; SytIV 
Gene Name
 Syt4 
Gene Synonyms/Alias
 Syt3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52SNKTPPYKFVHVLKGubiquitination[1]
84DKSEVKGKAALPNLSubiquitination[1]
98SLHLDLEKRDLNGNFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. 
Sequence Annotation
 DOMAIN 155 258 C2 1.
 DOMAIN 289 392 C2 2.
 REGION 147 297 Phospholipid binding (Probable).
 METAL 184 184 Calcium 1 (By similarity).
 METAL 184 184 Calcium 2 (By similarity).
 METAL 191 191 Calcium 1 (By similarity).
 METAL 245 245 Calcium 1; via carbonyl oxygen (By
 METAL 246 246 Calcium 1 (By similarity).
 METAL 246 246 Calcium 2 (By similarity).
 METAL 246 246 Calcium 3 (By similarity).
 METAL 249 249 Calcium 3 (By similarity).
 METAL 252 252 Calcium 2 (By similarity).
 METAL 252 252 Calcium 3 (By similarity).  
Keyword
 Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Metal-binding; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MAPITTSRVE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR RSAKSNKTPP YKFVHVLKGV 60
DIYPENLSSK KKFGGDDKSE VKGKAALPNL SLHLDLEKRD LNGNFPKANP KAGSSSDLEN 120
VTPKLFTETE KEANSPESLK SSTSLTSEEK QEKLGTLFLS LEYNFEKKAF VVNIKEAQGL 180
PAMDEQSMTS DPYIKMTILP EKKHRVKTRV LRKTLDPVFD ETFTFYGIPY PHIQELSLHF 240
TVLSFDRFSR DDVIGEVLIP LSGIELSDGK MLMTREIIKR NAKKSSGRGE LLVSLCYQST 300
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 360
DIPCESLEEI SVEFLVLDSE RGSRNEVIGR LVLGATAEGS GGGHWKEICD FPRRQIAKWH 420
MLCDG 425 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; TAS:UniProtKB.
 GO:0043005; C:neuron projection; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0007269; P:neurotransmitter secretion; IDA:MGI.
 GO:0017158; P:regulation of calcium ion-dependent exocytosis; TAS:UniProtKB.
 GO:0048489; P:synaptic vesicle transport; TAS:UniProtKB. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00399; SYNAPTOTAGMN.