UniProt Accession

 SDCB1_RAT; Q9JI92 

Genbank Protein ID

 AF248548; AJ292243; BC064651 

Genbank Nucleotide ID

 AAF86960.1; CAC21602.1; AAH64651.1 

Protein Name

 Syntenin-1 

Protein Synonyms/Alias

 Syndecan-binding protein 1 

Gene Name

 Sdcbp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
11	YPSLEDLKVDKVIQA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 

Sequence Annotation

 DOMAIN 116 195 PDZ 1.
 DOMAIN 200 274 PDZ 2.
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005895; C:interleukin-5 receptor complex; ISS:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005137; F:interleukin-5 receptor binding; ISS:UniProtKB.
 GO:0042043; F:neurexin family protein binding; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0042327; P:positive regulation of phosphorylation; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara. 

Interpro

 IPR001478; PDZ. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS