CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malic enzyme 
Protein Synonyms/Alias
  
Gene Name
 Me3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
47PPRPVPLKKRGYDVTacetylation[1]
254KHQRVRGKEYDDLLDacetylation[1]
359LEKEGIPKTEAVRKIacetylation[1]
372KIWMVDSKGLIVKGRacetylation[1]
472FASGSPFKSVTLEDGacetylation[1]
559KVLDYAYKHNLASYYacetylation[1]
570ASYYPEPKDKEAFIKacetylation[1]
597LDTYTWPKEAMSVQKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 80 80 Proton donor (By similarity).
 ACT_SITE 137 137 Proton donor (By similarity).
 ACT_SITE 151 151 Proton acceptor (By similarity).
 ACT_SITE 208 208 Proton acceptor (By similarity).
 METAL 280 280 Divalent metal cation (By similarity).
 METAL 281 281 Divalent metal cation (By similarity).
 METAL 304 304 Divalent metal cation (By similarity).  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MGAALGTGAR LTSLPRLACG SLRRQALSAP AQGCHSKSGP PRPVPLKKRG YDVTRNPHLN 60
KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYENQ QSDLDKYIIL MTLQDRNEKL 120
FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHIAT MLNSWPEDNI 180
KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD 240
PLYIGLKHQR VRGKEYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 300
FNDDIQGTAS VAVAGILAAL RITKNRLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGIPKT 360
EAVRKIWMVD SKGLIVKGRS HLNHEKEMFA QEHPEVNSLE EVVRLVKPTA IIGVAAIAGA 420
FTEQILRDMA SFHERPIIFA LSNPTSKAEC TAEKCYQVTE GRGIFASGSP FKSVTLEDGR 480
TFIPGQGNNA YVFPGVALGI IAGGIRHVPD EIFLLTAEVA AWNIKHVEET RIQEVRGTES 540
AVQPAVASQR TKVLDYAYKH NLASYYPEPK DKEAFIKSLI YTPDYDSFSL DTYTWPKEAM 600
SVQKV 605 
Gene Ontology
 GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 
Interpro
 IPR015884; Malic_enzyme_CS.
 IPR012301; Malic_N.
 IPR012302; Malic_NAD-bd.
 IPR001891; Malic_OxRdtase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00390; malic
 PF03949; Malic_M 
SMART
 SM00919; Malic_M 
PROSITE
 PS00331; MALIC_ENZYMES 
PRINTS
 PR00072; MALOXRDTASE.