CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis protein 7 
Protein Synonyms/Alias
  
Gene Name
 Dock7 
Gene Synonyms/Alias
 Gm430; Kiaa1771 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177QDEQDDLKRRSMSIDubiquitination[1]
1394KSKDMRAKLEEAILGubiquitination[1]
2078SLIGPDQKEYQRELEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). 
Sequence Annotation
 DOMAIN 561 727 DHR-1.
 DOMAIN 1668 2104 DHR-2.
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 30 30 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphoserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 439 439 Phosphoserine.
 MOD_RES 440 440 Phosphoserine.
 MOD_RES 882 882 Phosphoserine (By similarity).
 MOD_RES 888 888 Phosphoserine (By similarity).
 MOD_RES 896 896 Phosphoserine (By similarity).
 MOD_RES 900 900 Phosphoserine.
 MOD_RES 905 905 Phosphoserine (By similarity).
 MOD_RES 907 907 Phosphothreonine (By similarity).
 MOD_RES 909 909 Phosphothreonine (By similarity).
 MOD_RES 910 910 Phosphoserine (By similarity).
 MOD_RES 963 963 Phosphoserine.
 MOD_RES 965 965 Phosphothreonine.
 MOD_RES 1382 1382 Phosphoserine (By similarity).
 MOD_RES 1420 1420 Phosphoserine (By similarity).
 MOD_RES 1422 1422 Phosphoserine.
 MOD_RES 1428 1428 Phosphoserine.
 MOD_RES 1952 1952 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Guanine-nucleotide releasing factor; Neurogenesis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2130 AA 
Protein Sequence
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 60
EDYLVTHPLS GDSGPLRDLV EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 120
TEDWAVVVRK YHKLGTGFNP NTLDKQKERQ KGLPRQVFES DEAPDGSSYQ DEQDDLKRRS 180
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID HQNDDQRKSN RHKELFALHP 240
SPDEEEPIER LSVPDVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 300
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 360
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 420
EVEISTGERK GSWSERRNSS LVGRRSLERT TSGDDACNLT SFRPATLTVA NFFKQEGDRL 480
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 540
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 600
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 660
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 720
NVEVVAVSSI HTQDPYLDKF FALVNALDEH MFPVRIGDMR IMENNLESEL KSSISALNSS 780
QLEPVVRFLH LLLDKLILLV VRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 840
RNNLLASYIY YVFRLPNTYP NSPSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 900
NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGPKAAPW GSNPSPSAES TQAMDRSCNR 960
MSSHTETSSF LQTLTGRLPT KKLFHEELAL QWVVCSGSVR ESALQQAWFF FELMVKSMVH 1020
HLYFNDKLDA PRESRFPERF MDDIAALVST IAGDVVSRFQ KDTEMVERLN TSLAFFLNDL 1080
LSVMDRGFVF SLIKSCYKQV SAKLYSLPNP SVLVSLRLDF LRIICSHEHY VTLNLPCSLL 1140
TPPASPSPSV SSATSQSSGF STSVQDQKIA NMFELSLPFR QQHYLAGLVL TELALILDPD 1200
AEGLFGLHKK VINMVHNLLS THDSDPRYSD PQIKARVAML YLPLIGIIME TVPQLYDFTE 1260
SHNQRGRPIC IAPDDYDSES GSMISQTVAM AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS 1320
AESSRSLLIC LLWVLKNADE TVLQKWFTDL SVLQLNRLLD LLYLCVSCFE YKGKKVFERM 1380
NSLTFKKSKD MRAKLEEAIL GSIGARQEMV RRSRGQLERS PSGSAFGSQE NLRWRKDMTH 1440
WRQNSEKLDK SRAEIEHEAL IDGNLATEAN LIILDTLEII VQTVSVTESK ESILGGVLKV 1500
LLQSMACNQS AVYLQHCFAT QRALVSKFPE LLFEEETEQC ADLCLRLLRH CSSSISTIRS 1560
HASASLYLLM RQNFEIGNNF ARVKMQVTMS LSSLVGTSQN FNEEFLRRSL KTILTYAEED 1620
LELRETTFPD QVQDLVFNLH MILSDTVKMK EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW 1680
LQNMAGKHSE RSNHAEAAQC LVHSAALVAE YLSMLEDRKY LPVGCVTFQN ISSNVLEESA 1740
VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ AAASFSMAGM YEAVNEVYKV LIPIHEANRD 1800
AKKLSTIHGK LQEAFSKIVH QSTGWERMFG TYFRVGFYGT KFGDLDEQEF VYKEPAITKL 1860
AEISHRLEGF YGERFGEDVL EVIKDSNPVD KCKLDPNKAY IQITYVEPFF DTYEMKDRIT 1920
YFDKNYNLRR FMYCTPFTLD GRAHGELHEQ FKRKTILTTS HAFPYIKTRV NVTHKEEIIL 1980
TPIEVAIEDM QKKTQELAFA THQDPADPKM LQMVLQGSVG TTVNQGPLEV AQVFLSEIPG 2040
DPKLFRHHNK LRLCFKDFTK RCEDALRKNK SLIGPDQKEY QRELERNYHR LKEALQPLIN 2100
RKIPQLYKAV LPVTCHRDSF SRMSLRKMEL 2130 
Gene Ontology
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS