CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035589
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Spta1 
Protein Synonyms/Alias
  
Gene Name
 Spta1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
305EALFHSHKRLERNLAacetylation[1]
327ELCAKADKLMVSHSAacetylation[1]
786PLATRKKKLIDLLKLacetylation[1]
1133KSNEPRLKDINKVADacetylation[1]
2129DVLGRIWKHLPEIIKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2416 AA 
Protein Sequence
MERGKETAVE SSGPKVLETA EEIQHRRQEV LDQYQRFKER VAERGQKLEE SYHYQVFRRD 60
ADDLEKWIME KLEITKDKTY EPTNIQGKYQ KHESFVSEVQ AKSRVLPELE EIREARFAED 120
HFAHEATKTH LKELRHLWDL LLELTQEKSD ILLRALKFYQ YCQECEDILE WVKEKEAIVT 180
LVELGDDWER TEVLHKKFEE FQEELTARKG KVDRVNQYAN ECAQEQHPKL PEIKAKQDEV 240
NAAWDRLWSL ALKRRESLSN AADLQRFKRD VNEAIQWMEE KEPLLTSEDY GKDLVSSEAL 300
FHSHKRLERN LAVMDDKVKE LCAKADKLMV SHSADAPQIQ QMKMDLVSNW ELIRALATNR 360
YAKLKASYGY HRFLSDYDEL TGWMEEKTAL INADELPTDV ASGEALLARH QQHKHEIDSY 420
DDRFQTAEAT GQDLLDGNHE ASDEIREKMT ILAHDWAALR ELWNKCQHQY RQSLDFHLFY 480
RDSEQVDSWM SRQEAFLENE DLGNSVGSVE ALLQKHDDFE EAFTAQEEKI ITLDETATKL 540
IDNDHYDSEN IAAIRDGLLA RRDALRERAA TRRKLLVDSQ LLQQLYQDSD DLKTWINKKK 600
KLADDEDYKD VQNLKSRVQK QQDFEEELAA NEIMLNNLER TGQDMIENDH YASDAVAARM 660
SEVANLWKEL LEATAQKGTQ LYEANQLLQF ENNAEDLKRW LEEVERQVAS EDYGKGLADV 720
QNLLRKHGLL ESAVLARQDQ VDTLTDMAAH FEEIGHPDSE NICARQESLL SRFEALKEPL 780
ATRKKKLIDL LKLQQICRDS EDEEAWIQET EPSAASTHLG KDLVAAKNLL NRHEVILADI 840
ASHEPRIQTI TERGNKMVEE GHFASEDIAS RVESLNKNME SLRARAIRRE NDLKANVQLQ 900
QYLADLHEAE AWIKEKEPIV DNKNYGADEE AAGALLKKHE AFLVDLNAFG NSIKALGDQA 960
EACQQQQAAP VDEAGREARV IALYDFEARS RREVSMKKND VLTLLSSINK DWWKVEADDH 1020
QGFVPAVYVR KLAHDELPGF PQQRREEPVN IPQLQEQIET LYHSLLDRAE ERRRRLLQRY 1080
NEFLLAYEAG DMLEWIQEKK TENTGVELDD VWELQKKFDE FQRDLKSNEP RLKDINKVAD 1140
ELLFEDLLTP EGSHIRQELN TRWSSLKRLA DEQYQLLSSA HAVEMFLREA DDVKEQIDKK 1200
CQALNAADPG SDLLSVQALQ RQHEVFERDI IPLGEKVTTL GETAERLCES HPDATEDLQK 1260
QRTELNEAWD TLQGLTSDRK ESLNEAHKFF LFLSKASDLE NWIKAIGGVI SSPELAEDLT 1320
GTEILLERHQ EHYDDIKRED PTFQALEDFG RELIDRGHRN SHEIETTLQD IKLKRDDLEK 1380
NWENRKKMLD QCLELQLFRG KCEQVESWMV ARENSLRSDD RDHLNSLQAL MKKRDDLDKA 1440
IAAQEGKIAD LENHATRLMD NDHYAKEEIA ARLQRVLDRW KDLKTQLLAE LGKLGDYADL 1500
KQFYRDLEDL EEWISEMLPV ACDESYKDPT NIQQRKYLKH QAFENEVNGR AEQVEGVINL 1560
GKSLIERRVC DGDEENMQEQ LDKLKENWDY LLERTTDKGQ KLNEASRQQR FNTSIRDFEF 1620
WLSEAEGLLA MKDQARDLTS AGNLLKKHQL LEAEMLARED PLKDLNGLAK ELISSGTFNI 1680
EQIEEKMNGV NERFKNVQSL AAAHHEKLKE TYALFQFFQD LDDEEAWIEE KLLRVSSQDC 1740
GRDLQSVQNL LKKHRRLEGE LVAHEPAVQN VLDTAESLKD KAAVGKEEIQ ERLAQFVQHW 1800
EKLKELAKTR GVNLEESLQY LQFMENAEEE EAWLGEKDAL VSRGDSGDTL AATQSLLKKH 1860
EALENDFAVH KNRVQDVCAQ GEDILSKEET QNKDKISTKI EVLNEKTASL TKALAAWKSQ 1920
LDEVHAFQQF NWKADVVESW IGEKEASLKT KSNGADLTAF LTLLAKQDTL DASLQSFQQE 1980
RLSEITDLKD ELLAAEHSQS KAIEERHAAL LRRWEQLLEA CRVHRQKLLE KQLPLQKAEE 2040
LFMEFAHKAS AFNNWCENAE EDLSEPVHCV SLNEIRQLQK EHEAFLASMV GAQEDFNYLL 2100
ALDQQIKALN VSSSPYTWLT VDVLGRIWKH LPEIIKEREQ ELQKEEARQI KNFEMCQEFE 2160
QNASAFLQWI QETRAYFLDG SLLKETGTLE SQLEANKRKQ KEIQAMKRHL TKIEDLGDSM 2220
EEALILDIKY STIGLAQQWD QLHQLGMRMQ HNLEQQIQAK DTIGVSEETL KEFSTTYKHF 2280
DENLTGRLTH KEFRSCLRGL NYYLPMVEEG EPEPKFEKFL NAVDPGRKGY VSLEDYTSFL 2340
IDKESENIKT SDDIESGFQA LAEGKAYITK EDMKQALTPE QVSFCTIHMQ QYMDPRGRSQ 2400
PAGYDYVGFT NSFFGN 2416 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR014837; EF-hand_Ca_insen.
 IPR002048; EF_hand_dom.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR013315; Spectrin_alpha_SH3.
 IPR002017; Spectrin_repeat. 
Pfam
 PF08726; efhand_Ca_insen
 PF00018; SH3_1
 PF00435; Spectrin 
SMART
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS50222; EF_HAND_2
 PS50002; SH3 
PRINTS
 PR01887; SPECTRNALPHA.