UniProt Accession

 NNRE_HUMAN; Q8NCW5; B4DGY3; Q496C6; Q5T3I2 

Genbank Protein ID

 AJ315849; AK294835; AL365181; BC100931; BC100932; BC100933; BC100934 

Genbank Nucleotide ID

 CAC86580.1; BAG57944.1; CAI13051.1; AAI00932.1; AAI00933.1; AAI00934.1; AAI00935.1 

Protein Name

 NAD(P)H-hydrate epimerase 

Protein Synonyms/Alias

 Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase; YjeF N-terminal domain-containing protein 1; YjeF_N1 

Gene Name

 APOA1BP 

Gene Synonyms/Alias

 AIBP; YJEFN1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	LVCARHLKLFGYEPT	ubiquitination	[1, 2]
269	FVPPALEKKYQLNLP	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). 

Sequence Annotation

 DOMAIN 65 275 YjeF N-terminal.
 REGION 119 123 NAD(P)HX (By similarity).
 REGION 189 195 NAD(P)HX (By similarity).
 METAL 120 120 Potassium (By similarity).
 METAL 185 185 Potassium (By similarity).
 METAL 221 221 Potassium (By similarity).
 BINDING 218 218 NAD(P)HX (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Isomerase; Metal-binding; Mitochondrion; NAD; NADP; Nucleotide-binding; Phosphoprotein; Polymorphism; Potassium; Reference proteome; Secreted; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0005615; C:extracellular space; ISS:BHF-UCL.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0052856; F:NADHX epimerase activity; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0051289; P:protein homotetramerization; IEA:Compara. 

Interpro

 IPR026600; NnrE/AIBP.
 IPR004443; YjeF_N_dom. 

Pfam

 PF03853; YjeF_N 

SMART

  

PROSITE

 PS51385; YJEF_N 

PRINTS