CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mini-chromosome maintenance complex-binding protein 
Protein Synonyms/Alias
 MCM-BP; MCM-binding protein 
Gene Name
 Mcmbp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
436QLKLIPHKDYTANRLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). 
Sequence Annotation
 MOD_RES 154 154 Phosphoserine (By similarity).
 MOD_RES 160 160 Phosphothreonine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).  
Keyword
 Cell cycle; Cell division; Complete proteome; DNA replication; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 642 AA 
Protein Sequence
MPCGEDWLSH PLGIVQGFFA QNGVNPDWEK KVIEYFKEKL KENNAPKWVP SLNEVPLHYL 60
KPNSFVKFRC MIQDMFDPEF YMGIYETVNQ NTKARVLHFG KYRDVAECGP QQELDLSSPR 120
STTSERQTFY CVPVPGESSW VKEAYVNANQ ARVSPSTSYT PSRHKRSYED DEDMDLQPSK 180
QKEQHPGSRQ AGGLGGLHWC GEPKRLETEA SSGQQLNTLN LSSPFDLNFP LPGEKGPACL 240
VKVYEDWDCF KVNDVLELYG VLSVDPVLSV LNSEERDASA LLDPMECTDM AEEQRVHSPP 300
ASLVPRIHVI LAQKLQHINP LLPTCLNKEE SRSCQFVSNF MSELSPVRAE LLGFLTHALL 360
GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPQNS TFTEHLYRII QHLVPASFRL 420
QMTIENMNQL KLIPHKDYTA NRLVSGLLQL PNNTSLVIDE TLLEQGQLDT PGVHNVTALS 480
NLITWQKVDY DFSYHQMEFP CNINVLITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNGLL 540
SAVLPSVLNK FRIYLTLLRF LDYNLSDDIT KAVEDDFVEM RKDDPQSITA DDLHQLLVVA 600
RFLSLSVGQT TLSRERWLRA KQLELSRKAR LQQQKSVNGN EL 642 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0042555; C:MCM complex; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003682; F:chromatin binding; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006261; P:DNA-dependent DNA replication; ISS:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000084; P:S phase of mitotic cell cycle; ISS:UniProtKB.
 GO:0007062; P:sister chromatid cohesion; ISS:UniProtKB. 
Interpro
 IPR019140; MCM_complex-bd. 
Pfam
 PF09739; MCM_bind 
SMART
  
PROSITE
  
PRINTS