| Tag | Content |
|---|
| CPLM ID | CPLM-001708 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G1/S-specific cyclin-E2 |
Protein Synonyms/Alias | |
Gene Name | CCNE2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 31 | EAQIIQAKKRKTTQD | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Essential for the control of the cell cycle at the late G1 and early S phase. |
Sequence Annotation | MOD_RES 21 21 Phosphoserine.
MOD_RES 383 383 Phosphoserine.
MOD_RES 392 392 Phosphothreonine. |
Keyword | Alternative splicing; Cell cycle; Cell division; Complete proteome; Cyclin; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 404 AA |
Protein Sequence | MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH QYEIRNCWPP 60
VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWGCS KEVWLNMLKK 120
ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI 180
NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP 240
VTIISWLNLF LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA 300
LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP MEDRHNIQTH 360
TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP PGKH 404 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:Compara. GO:0000075; P:cell cycle checkpoint; TAS:ProtInc. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0006270; P:DNA replication initiation; IEA:Compara. GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome. GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |